Evidence map›Paper›PMID 36196444›Full record

ArticleJAC-antimicrobial resistance2022

Prevalence of carbapenemase genes among carbapenem-nonsusceptible

Mariana Castanheira, Lalitagauri M Deshpande, Rodrigo E Mendes, Timothy B Doyle, Helio S Sader

Abstract read
In one paragraph

Article in JAC-antimicrobial resistance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Antimicrobial agents and chemotherapy · 2025
    Review
  8. In vitro activity and resistance mechanisms of novel antimicrobial agents against metallo-β-lactamase producers.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Review
  9. Carbapenem-ResistantCase reports in infectious diseases · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Molecular Epidemiology of Carbapenem-ResistantInternational journal of molecular sciences · 2024
    Article
  16. Review
  17. Article
  18. Novel Antimicrobial Agents for Gram-Negative Pathogens.Antibiotics (Basel, Switzerland) · 2023
    Review
  19. Trends of β-Lactamase Occurrence AmongOpen forum infectious diseases · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mariana CastanheiraJMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA.ORCID https://orcid.org/0000-0003-0126-1782
Lalitagauri M DeshpandeJMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA.ORCID https://orcid.org/0000-0003-1709-1132
Rodrigo E MendesJMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA.ORCID https://orcid.org/0000-0002-8648-1137
Timothy B DoyleJMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA.ORCID https://orcid.org/0000-0002-1083-8742
Helio S SaderJMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA.ORCID https://orcid.org/0000-0001-7022-6644

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To evaluate the prevalence of acquired β-lactamase genes and susceptibility profiles of carbapenem-nonsusceptible Methods: Isolates were susceptibility tested by reference broth microdilution methods. Results were interpreted using CLSI breakpoints. Isolates displaying nonsusceptible MICs for imipenem or meropenem were categorized as CNSE. CNSE isolates were screened for β-lactamase-encoding genes using whole-genome sequencing. New genes were cloned, expressed in an Results: A total of 450 (1.3%) isolates were CNSE. Conclusions: A decline in carbapenemase production was noticed in US hospitals in the 5-year period analysed in this study. New β-lactam/β-lactamase inhibitor combinations tested had good activity against CNSE isolates.

Identifiers

PMID36196444
PMCPMC9524567

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.