Evidence map›Paper›PMID 36196007›Full record

ArticleThe Journal of nutrition2023

Maternal Periconceptional Folic Acid Supplementation and DNA Methylation Patterns in Adolescent Offspring.

Krista S Crider, Arick Wang, Hao Ling, Nancy Potischman, Regan L Bailey, Yang Lichen, Christine M Pfeiffer, J Keith Killian, Charles Rose, Joshua Sampson and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Krista S CriderNational Center on Birth Defects and Developmental Disabilities, US CDC, Atlanta, GA, USA.ORCID 0000-0001-6997-5955
Arick WangNational Center on Birth Defects and Developmental Disabilities, US CDC, Atlanta, GA, USA.ORCID 0000-0002-6768-6153
Hao LingUS CDC China Office, Beijing, China.
Nancy PotischmanOffice of Dietary Supplements, NIH, Bethesda, MD, USA.
Regan L BaileyDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.ORCID 0000-0003-0181-6223
Yang LichenNational Center for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, China.
Christine M PfeifferDivision of Laboratory Sciences, National Center for Environmental Health, US CDC, Atlanta, GA, USA.
J Keith KillianCenter for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Charles RoseNational Center on Birth Defects and Developmental Disabilities, US CDC, Atlanta, GA, USA.
Joshua SampsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Li ZhuSchool of Public Health, Peking University Health Science Center, Beijing, China (retired).
Robert J BerryNational Center on Birth Defects and Developmental Disabilities, US CDC, Atlanta, GA, USA.
Martha LinetDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Wang YuDirector General (former), Chinese Center for Disease Control and Prevention, Beijing, China.
L Joseph SuCancer Prevention and Population Sciences Program, Division of Epidemiology, University of Arkansas, Little Rock, AR, USA.
National Center on Birth Defects and Developmental Disabilities · USNational Cancer Institute · USChinese Center For Disease Control and Prevention · CNNational Center for Environmental Health · USOffice of Dietary Supplements · USPeking University · CNPurdue University West Lafayette · USUniversity of Arkansas at Little Rock · US

Funding

Studies of other risk factors for radiosensitive tumorsZIACP010219 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI KITAHARA, CARI · 2011 to 2025
$6.0M
CDC HHSIntramural CDC HHS CC999999NCI NIH HHS
6 · The paper itself

Abstract

backgroundFolate, including the folic acid form, is a key component of the one-carbon metabolic pathway used for DNA methylation. Changes in DNA methylation patterns during critical development periods are associated with disease outcomes and are associated with changes in nutritional status in pregnancy. The long-term impact of periconceptional folic acid supplementation on DNA methylation patterns is unknown.

objectivesTo determine the long-term impact of periconceptional folic acid supplementation on DNA methylation patterns, we examined the association of the recommended dosage (400 μg/d) and time period (periconceptional before pregnancy through first trimester) of folic acid supplementation with the DNA methylation patterns in the offspring at age 14-17 y compared with offspring with no supplementation.

methodsTwo geographic sites in China from the 1993-1995 Community Intervention Program of folic acid supplementation were selected for the follow-up study. DNA methylation at 402,730 CpG sites was assessed using saliva samples from 89 mothers and 179 adolescents (89 male). The mean age at saliva collection was 40 y among mothers (range: 35-54 y) and 15 y among adolescents (range: 14-17 y). Epigenome-wide analyses were conducted to assess the interactions of periconceptional folic acid exposure, the 5,10-methylenetetrahydrofolate reductase (MTHFR)-C677T genotype, and epigenome-wide DNA methylation controlling for offspring sex, geographic region, and background cell composition in the saliva.

resultsIn the primary outcome, no significant differences were observed in epigenome-wide methylation patterns between adolescents exposed and those non-exposed to maternal periconceptional folic acid supplementation after adjustment for potential confounders [false discovery rate (FDR) P values < 0.05]. The MTHFR-C677T genotype did not modify this lack of association (FDR P values < 0.05).

conclusionsOverall, there were no differences in DNA methylation between adolescents who were exposed during the critical developmental window and those not exposed to the recommended periconceptional/first-trimester dosage of folic acid.

Indexed as

Dietary SupplementsDNA MethylationAdolescentFemaleFolic AcidFollow-Up StudiesHumansMaleMothersPregnancyFolic Acidadolescentsdietary supplementsDNA methylationepigeneticfolic acidpericonceptionalpregnancy

Identifiers

PMID36196007
PMCPMC9839994
OpenAlexW4301394421

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.