Evidence map›Paper›PMID 36195934›Full record

ArticleTrials2022

Psychosocial stress induction in vivo vs. in virtuo and the influence of a health app on the acute stress reaction in youths: a study protocol for a randomized controlled trial.

Daniel Schleicher, Angelika Ecker, Martin Kocur, Irina Jarvers, Colin Nash, Leonie Götz, Alexandra H Otto, Stephanie Kandsperger, Romuald Brunner

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Daniel Schleicher *Clinic of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany. Daniel.Schleicher@medbo.de.
Angelika Ecker *Clinic of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany.
Martin KocurDepartment of Media Informatics, University of Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.
Irina JarversClinic of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany.
Colin NashClinic of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany.
Leonie GötzClinic of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany.
Alexandra H OttoClinic of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany.
Stephanie KandspergerClinic of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany.
Romuald BrunnerClinic of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany.
University of Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute and everyday stress is substantial for the development of mental and physical diseases, therefore it is crucial to get a better understanding of its pathogenesis. Different methods (e.g., Ambulatory Assessment) and stress reactivity paradigms (e.g., Trier Social Stress Test / TSST) in laboratory settings are often used to investigate basic mechanisms of this process. Due to the technological progress of the last years and especially due to children and adolescents growing up with it, the application of these developments in clinical research is reasonable. The aim of this project is to successfully transfer the TSST for children and adolescents into the virtual world, which will be compared to a real TSST situation. Physiological and psychological stress reactions will be analyzed in order to assess similarities and differences. Moreover, it will be investigated whether a Heart Coherence Exercise (HCE) has a stronger influence on coping with acute stress compared to Natural Relaxation (NR).

methodsThis single-center experimental study will examine acute and everyday stress and coping processes in eighty-four healthy children and adolescents between the ages of 11 and 17. For everyday stress, different parameters (e.g., hormonal profiles and mood ratings) as well as a history of stressful life events and utilized coping methods will be recorded and a relaxation exercise will be practiced on a smartphone over 2 days. Regarding the acute stress reaction, the participants will be confronted either with the virtual or the real version of the TSST, followed by the trained relaxation exercise (HCE vs. NR). Physiological (e.g., cortisol and heart rate) and psychological stress markers (e.g., mood and gaze behavior) will be recorded continuously. DISCUSSION: Studies are sparse using a virtual version of the TSST in children and adolescents. A successful virtual TSST would constitute an economical variant, which would also make it easier to administer it in clinical or population-based samples. Effective ambulatory relaxation exercises would be a useful addition to clinical treatment approaches.

trial registrationThe study is registered in the German Clinical Trials Register since 10 August 2020 ( DRKS00022063 ).

Indexed as

HydrocortisoneMobile ApplicationsAdolescentChildDieldrinHumansPsychological TestsRandomized Controlled Trials as TopicSalivaStress, PsychologicalDieldrinHCEHydrocortisoneAmbulatory AssessmentChildren and adolescentsCopingCortisolEye-trackingRelaxationStress mechanismsTrier Social Stress TestVirtual reality

Identifiers

PMID36195934
PMCPMC9531435
OpenAlexW3150661235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.