ArticleBMC medical genomics2022
Genetic liability to obesity and peptic ulcer disease: a Mendelian randomization study.
Article in BMC medical genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 107 citations in OpenAlex.
- Plasma vitamin D levels in obese individuals with peptic ulcer disease from NAHSIT databank of Taiwan.Scientific reports · 2025Article
- Adolescent Obesity and Charlson Comorbidity Index in Young Adults.Journal of clinical medicine · 2025Article
- Article
- Use ofPeerJ · 2024Article
- Evidence for causal effects of polycystic ovary syndrome on oxidative stress: a two-sample mendelian randomisation study.BMC medical genomics · 2023Article
- Citral Modulates MMP-2 and MMP-9 Activities on Healing of Gastric Ulcers Associated with High-Fat Diet-Induced Obesity.International journal of molecular sciences · 2023Article
- Stroke and the risk of gastrointestinal disorders: A Mendelian randomization study.Frontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEpidemiological evidence relating obesity to peptic ulcer disease (PUD) has been mixed. Here we sought to determine the causality in the association of obesity with PUD risk using the Mendelian randomization (MR) approach.
methodsThis study was based on summary-level data for body mass index (BMI), waist-to-hip ratio (WHR), and PUD derived from large genome-wide association studies (GWASs). Single nucleotide polymorphisms significantly associated with BMI and WHR (P < 5 × 10
resultsGenetically predicted higher BMI has a causal effect on PUD, with an OR of 1.34 per SD increase in BMI (~ 4.8 kg/m
conclusionsThis MR study revealed that obesity (notably abdominal obesity) is causally associated with higher PUD risk. Programs aimed at weight loss may represent therapeutic opportunities for PUD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.