ArticleBMC women's health2022
COVID-19 vaccine and menstrual conditions in female: data analysis of the Vaccine Adverse Event Reporting System (VAERS).
Article in BMC women's health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Prevalence of menstrual alterations following COVID-19 vaccination: systematic review & meta-analysis.BMC women's health · 2024Pooled it
- Menstrual disorders following COVID-19 vaccination: a review using a systematic search.Frontiers in drug safety and regulation · 2024Pooled it
- COVID-19 vaccination and menstrual disorders among women: Findings from a meta-analysis study.Journal of infection and public health · 2023Pooled it
- Effect of COVID-19 vaccination on the menstrual cycle.Frontiers in medicine · 2022Pooled it
- Article
- Menstrual Disorders Following Covid 19 Vaccination in Women of Reproductive Age and Post-Menopause. A Systematic Review.Health science reports · 2025Review
- Impact of COVID-19 Vaccination on Menstrual Irregularities, Bleeding Patterns, and Cycle Duration: A Systematic Review and Meta-Analysis.Health science reports · 2025Review
- Coronavirus disease vaccine linked menstrual changes: mobile application study.Obstetrics & gynecology science · 2025Article
- The prevalence of menstrual changes in COVID-19 vaccinated women: A cross-sectional study.Preventive medicine reports · 2024Article
- Association between COVID-19 vaccination and menstruation: a state of the science review.BMJ sexual & reproductive health · 2024Review
- Abnormal uterine bleeding diagnoses and care following COVID-19 vaccination.American journal of obstetrics and gynecology · 2024Article
- Impact of COVID-19 infections and vaccination on menstrual cycle symptoms in the south of Jordan: a cross-sectional study.The Journal of the Egyptian Public Health Association · 2024Article
- Unexpected vaginal bleeding and COVID-19 vaccination in nonmenstruating women.Science advances · 2023Article
- Association between SARS-CoV-2 vaccination and healthcare contacts for menstrual disturbance and bleeding in women before and after menopause: nationwide, register based cohort study.BMJ (Clinical research ed.) · 2023Article
- Article
- Association between COVID-19 vaccines and the menstrual cycle in young Japanese women.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2023Article
- Can COVID-19 Vaccines Induce Premature Non-Communicable Diseases: Where Are We Heading to?Vaccines · 2023Review
- Article
- Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn reports of adverse reactions following vaccination with the coronavirus disease 2019(COVID-19) vaccines, there have been fewer reports of concern for menstrual disorders in female.
objectiveOur study employed Vaccine Adverse Event Reporting System (VAERS) to investigate and analyze the relationship between COVID-19 Vaccines and menstrual disorders in female.
methodsWe collected reports of menstrual disorders in VAERS from July 2, 1990 to November 12, 2021, and performed a stratified analysis. The potential relationship between COVID-19 vaccine and reports of menstrual disorders was evaluated using the Reporting Odds Ratio (ROR) method.
resultsA total of 14,431 reports of menstrual disorders were included in the study, and 13,118 were associated with COVID-19 vaccine. The ROR was 7.83 (95% confidence interval [95%CI]: 7.39-8.28). The most commonly reported event was Menstruation irregular (4998 reports), and a higher percentage of female aged 30-49 years reported menstrual disorders (42.55%) after exposure to COVID-19 Vaccines. Both for all reports of menstrual disorders (ROR = 5.82; 95%CI: 4.93-6.95) and excluding reports of unknown age (ROR = 13.02; 95%CI: 10.89-15.56),suggest that female age may be associated with menstrual disorders after vaccination with the COVID-19 Vaccines.
conclusionThere is a potential safety signal when the COVID-19 vaccine is administered to young adult female (30-49 years old), resulting in menstrual disorders in. However, due to the well-known limitations of spontaneous reporting data, it is challenging to explicity classify menstrual disorders as an adverse event of the COVID-19 Vaccines, and reports of adverse reactions to COVID-19 Vaccines in this age group should continue to be tracked.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.