Evidence map›Paper›PMID 36195861›Full record

ArticleBMC medical genomics2022

An association study of IL2RA polymorphisms with cerebral palsy in a Chinese population.

Yimeng Qiao, Yangong Wang, Yiran Xu, Jin Zhang, Yu Su, Ye Cheng, Dan Bi, Juan Song, Lei Xia, Ming Li and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Yimeng Qiao *Children's hospital of Fudan University; and Institutes of Biomedical Sciences of Fudan University, Wanyuan Road 399, Shanghai, 201102, China.
Yangong Wang *Children's hospital of Fudan University; and Institutes of Biomedical Sciences of Fudan University, Wanyuan Road 399, Shanghai, 201102, China.
Yiran Xu *Henan Key Laboratory of Child Brain Injury, Department of Pediatrics, the 3Rd Affiliated Hospital of Zhengzhou University and Institute of Neuroscience, Kangfuqian Street 7, Zhengzhou, 450052, China.
Jin ZhangChildren's hospital of Fudan University; and Institutes of Biomedical Sciences of Fudan University, Wanyuan Road 399, Shanghai, 201102, China.
Yu SuChildren's hospital of Fudan University; and Institutes of Biomedical Sciences of Fudan University, Wanyuan Road 399, Shanghai, 201102, China.
Ye ChengChildren's hospital of Fudan University; and Institutes of Biomedical Sciences of Fudan University, Wanyuan Road 399, Shanghai, 201102, China.
Dan BiHenan Key Laboratory of Child Brain Injury, Department of Pediatrics, the 3Rd Affiliated Hospital of Zhengzhou University and Institute of Neuroscience, Kangfuqian Street 7, Zhengzhou, 450052, China.
Juan SongHenan Key Laboratory of Child Brain Injury, Department of Pediatrics, the 3Rd Affiliated Hospital of Zhengzhou University and Institute of Neuroscience, Kangfuqian Street 7, Zhengzhou, 450052, China.
Lei XiaHenan Key Laboratory of Child Brain Injury, Department of Pediatrics, the 3Rd Affiliated Hospital of Zhengzhou University and Institute of Neuroscience, Kangfuqian Street 7, Zhengzhou, 450052, China.
Ming LiHenan Key Laboratory of Child Brain Injury, Department of Pediatrics, the 3Rd Affiliated Hospital of Zhengzhou University and Institute of Neuroscience, Kangfuqian Street 7, Zhengzhou, 450052, China.
Xiaoli ZhangHenan Key Laboratory of Child Brain Injury, Department of Pediatrics, the 3Rd Affiliated Hospital of Zhengzhou University and Institute of Neuroscience, Kangfuqian Street 7, Zhengzhou, 450052, China.
Dengna ZhuHenan Key Laboratory of Child Brain Injury, Department of Pediatrics, the 3Rd Affiliated Hospital of Zhengzhou University and Institute of Neuroscience, Kangfuqian Street 7, Zhengzhou, 450052, China.
Ting WangChildren's hospital of Fudan University; and Institutes of Biomedical Sciences of Fudan University, Wanyuan Road 399, Shanghai, 201102, China.
Jian DingChildren's hospital of Fudan University; and Institutes of Biomedical Sciences of Fudan University, Wanyuan Road 399, Shanghai, 201102, China.
Xiaoyang WangHenan Key Laboratory of Child Brain Injury, Department of Pediatrics, the 3Rd Affiliated Hospital of Zhengzhou University and Institute of Neuroscience, Kangfuqian Street 7, Zhengzhou, 450052, China.
Changlian ZhuHenan Key Laboratory of Child Brain Injury, Department of Pediatrics, the 3Rd Affiliated Hospital of Zhengzhou University and Institute of Neuroscience, Kangfuqian Street 7, Zhengzhou, 450052, China. zhuc@zzu.edu.cn.
Qinghe XingChildren's hospital of Fudan University; and Institutes of Biomedical Sciences of Fudan University, Wanyuan Road 399, Shanghai, 201102, China. xingqinghe@hotmail.com.
Third Affiliated Hospital of Zhengzhou University · CNChildren's Hospital of Fudan University · CNFudan University · CNUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCerebral palsy (CP), the most common physical disability of childhood, is a nonprogressive movement disorder syndrome. Eighty percent of cases are considered idiopathic without a clear cause. Evidence has shown that cytokine abnormalities are widely thought to contribute to CP.

methodsAn association between 6 SNPs (rs12244380, rs2025345, rs12722561, rs4749926, rs2104286 and rs706778) in IL2RA (interleukin 2 receptor subunit alpha) and CP was investigated using a case-control method based on 782 CP cases and 778 controls. The allele, genotype and haplotype frequencies of SNPs were assessed using the SHEsis program. Subgroup analyses based on complications and clinical subtypes were also conducted.

resultsGlobally, no differences in genotype or allele frequencies for any SNPs remained significant after Bonferroni correction between patients and controls, except rs706778, which deviated from Hardy-Weinberg equilibrium and was excluded from further analyses. However, subgroup analysis revealed a significant association of rs2025345 with spastic tetraplegia (P genotype = 0.048 after correction) and rs12722561 with CP accompanied by global developmental delay (P allele = 0.045 after correction), even after Bonferroni correction.

conclusionsThese findings indicated that genetic variations in IL2RA are significantly associated with CP susceptibility in the Chinese Han population, suggesting that IL2RA is likely involved in the pathogenesis of CP. Further investigation with a larger sample size in a multiethnic population is needed to confirm the association.

Indexed as

Cerebral PalsyGenetic Predisposition to DiseaseCase-Control StudiesChinaCytokinesGene FrequencyGenotypeHumansInterleukin-2 Receptor alpha SubunitPolymorphism, Single NucleotideCytokinesIL2RA protein, humanInterleukin-2 Receptor alpha SubunitAssociation studyCerebral palsyChinese populationGene polymorphismIL2RA

Identifiers

PMID36195861
PMCPMC9531349
OpenAlexW4301396993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.