Evidence map›Paper›PMID 36195815›Full record

ArticleInternational ophthalmology2023

Effect of human umbilical cord mesenchymal stem cell exosomes on aerobic metabolism of human retinal pigment epithelial cells.

Lian Liu, Chunlan Liang, Wei Fan, Jingxiang Zhong

Abstract read
PubMed Publisher
In one paragraph

Article in International ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lian LiuDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou, 510630, Guangdong Province, China.ORCID http://orcid.org/0000-0002-5774-7602
Chunlan LiangDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou, 510630, Guangdong Province, China.
Wei Fan *Department of Ophthalmology, Hunan Aerospace Hospital, 189 Fenglin 3rd Road, Yuelu District, Changsha, 410006, Hunan Province, China.
Jingxiang ZhongDepartment of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 Huangpu Road, Guangzhou, 510630, Guangdong Province, China. zjx85221206@126.com.
First Affiliated Hospital of Jinan University · CNHunan Cancer Hospital · CN

Funding

Fundamental Research Funds for the Central Universities No.21621052National Natural Science Foundation of China No.81970806National Natural Science Foundation of China No.82101116
6 · The paper itself

Abstract

purposeTo investigate the effect of exosomes secreted by human umbilical cord mesenchymal stem cells (HUCMSC-Exo) on aerobic metabolism of cobalt chloride (CoCl

methodsHUCMSC-Exo were extracted and identified; CCK-8 assay was used to established the oxidative damage mode of ARPE-19 cells induced by CoCl

resultsUnder transmission electron microscope, HUCMSC-Exo were round or oval membrane vesicles with diameters of about 40-100 nm. Western blot results showed that HUCMSC-Exo expressed specific marker proteins CD63 and CD81. CCK-8 dates showed that the cell viability of ARPE-19 cells was significantly decreased with increasing CoCl

conclusionHUCMSC-Exo had a certain protective effect on ARPE-19 cells induced by CoCl

Indexed as

ExosomesMesenchymal Stem CellsAdenosine TriphosphateCobaltEpithelial CellsHumansRetinal PigmentsUmbilical CordAdenosine TriphosphateCobaltcobaltous chlorideRetinal PigmentsAerobic metabolismARPE-19 cellsATP synthesisHUCMSC exosomesOxidative damageRespiratory chains complex enzyme activity

Identifiers

PMID36195815
OpenAlexW4301372697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.