Evidence map›Paper›PMID 36195745›Full record

ArticleArchives of toxicology2022

Electronic cigarette vaping with aged coils causes acute lung injury in mice.

Shunsaku Goto, Robert M H Grange, Riccardo Pinciroli, Ivy A Rosales, Rebecca Li, Sophie L Boerboom, Katrina F Ostrom, Eizo Marutani, Hatus V Wanderley, Aranya Bagchi and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Vaping-associated illness: a reassessment.International journal of emergency medicine · 2024
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Shunsaku GotoAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA.
Robert M H GrangeAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA.
Riccardo PinciroliAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA.
Ivy A RosalesImmunopathology Research Laboratory, Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Rebecca LiCardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Sophie L BoerboomCardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Katrina F OstromCardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Eizo MarutaniAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA.
Hatus V WanderleyAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA.
Aranya BagchiAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA.
Robert B ColvinImmunopathology Research Laboratory, Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Lorenzo BerraAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA.
Olga MinaevaCenter for Biometals & Metallomics, Department of Radiology, Boston University School of Medicine, Boston University Alzheimer' Disease Center, Boston, MA, 02118, USA.
Lee E GoldsteinCenter for Biometals & Metallomics, Department of Radiology, Boston University School of Medicine, Boston University Alzheimer' Disease Center, Boston, MA, 02118, USA.
Rajeev MalhotraCardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Warren M ZapolAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA.
Fumito IchinoseAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA.
Binglan YuAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA. byu1@mgh.harvard.edu.ORCID 0000-0001-5496-2131
Harvard University · USMassachusetts General Hospital · USBoston University · US

Funding

National Institute for Health and Care Research 3R01-HL142809-03S1
6 · The paper itself

Abstract

Electronic cigarettes (e-cigarettes) have been used widely as an alternative to conventional cigarettes and have become particularly popular among young adults. A growing body of evidence has shown that e-cigarettes are associated with acute lung injury and adverse effects in multiple other organs. Previous studies showed that high emissions of aldehydes (formaldehyde and acetaldehyde) in aerosols were associated with increased usage of the same e-cigarette coils. However, the impact on lung function of using aged coils has not been reported. We investigated the relationship between coil age and acute lung injury in mice exposed to experimental vaping for 1 h (2 puffs/min, 100 ml/puff). The e-liquid contains propylene glycol and vegetable glycerin (50:50, vol) only. The concentrations of formaldehyde and acetaldehyde in the vaping aerosols increased with age of the nichrome coils starting at 1200 puffs. Mice exposed to e-cigarette aerosols produced from 1800, but not 0 or 900, puff-aged coils caused acute lung injury, increased lung wet/dry weight ratio, and induced lung inflammation (IL-6, TNF-α, IL-1β, MIP-2). Exposure to vaping aerosols from 1800 puff-aged coils decreased heart rate, respiratory rate, and oxygen saturation in mice compared to mice exposed to air or aerosols from new coils. In conclusion, we observed that the concentration of aldehydes (formaldehyde and acetaldehyde) increased with repeated and prolonged usage of e-cigarette coils. Exposure to high levels of aldehyde in vaping aerosol was associated with acute lung injury in mice. These findings show significant risk of lung injury associated with prolonged use of e-cigarette devices.

Indexed as

Acute Lung InjuryElectronic Nicotine Delivery SystemsVapingAcetaldehydeAldehydesAnimalsFormaldehydeGlycerolInterleukin-6MicePropylene GlycolRespiratory Aerosols and DropletsTumor Necrosis Factor-alphaAcetaldehydeAldehydesFormaldehydeGlycerolInterleukin-6Propylene GlycolTumor Necrosis Factor-alphaAcute lung injuryAged coilsAldehydee-cigaretteInflammationVaping aerosols

Identifiers

PMID36195745
OpenAlexW4301179380

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.