Evidence map›Paper›PMID 36195731›Full record

ArticlePsychopharmacology2022

Duration- and sex-dependent neural circuit control of voluntary physical activity.

Margaret K Tanner, Jazmyne K P Davis, Jennifer Jaime, Nicolette A Moya, Alyssa A Hohorst, Kelsey Bonar, Kelsey A Abrams, Nashra Jamil, Rebecca Han, Troy J Hubert and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Margaret K TannerDepartment of Psychology, University of Colorado Denver, PO Box 173364, North Classroom Rm. 5005 F, CB 173, Denver, CO, 80217-3364, USA.
Jazmyne K P DavisDepartment of Psychology, University of Colorado Denver, PO Box 173364, North Classroom Rm. 5005 F, CB 173, Denver, CO, 80217-3364, USA.
Jennifer JaimeDepartment of Psychology, University of Colorado Denver, PO Box 173364, North Classroom Rm. 5005 F, CB 173, Denver, CO, 80217-3364, USA.
Nicolette A MoyaDepartment of Psychology, University of Colorado Denver, PO Box 173364, North Classroom Rm. 5005 F, CB 173, Denver, CO, 80217-3364, USA.
Alyssa A HohorstDepartment of Psychology, University of Colorado Denver, PO Box 173364, North Classroom Rm. 5005 F, CB 173, Denver, CO, 80217-3364, USA.
Kelsey BonarDepartment of Psychology, University of Colorado Denver, PO Box 173364, North Classroom Rm. 5005 F, CB 173, Denver, CO, 80217-3364, USA.
Kelsey A AbramsDepartment of Psychology, University of Colorado Denver, PO Box 173364, North Classroom Rm. 5005 F, CB 173, Denver, CO, 80217-3364, USA.
Nashra JamilDepartment of Psychology, University of Colorado Denver, PO Box 173364, North Classroom Rm. 5005 F, CB 173, Denver, CO, 80217-3364, USA.
Rebecca HanDepartment of Psychology, University of Colorado Denver, PO Box 173364, North Classroom Rm. 5005 F, CB 173, Denver, CO, 80217-3364, USA.
Troy J HubertDepartment of Psychology, University of Colorado Denver, PO Box 173364, North Classroom Rm. 5005 F, CB 173, Denver, CO, 80217-3364, USA.
Nadja BrownDepartment of Psychology, University of Colorado Denver, PO Box 173364, North Classroom Rm. 5005 F, CB 173, Denver, CO, 80217-3364, USA.
Esteban C LoetzDepartment of Psychology, University of Colorado Denver, PO Box 173364, North Classroom Rm. 5005 F, CB 173, Denver, CO, 80217-3364, USA.
Benjamin N GreenwoodDepartment of Psychology, University of Colorado Denver, PO Box 173364, North Classroom Rm. 5005 F, CB 173, Denver, CO, 80217-3364, USA. benjamin.greenwood@ucdenver.edu.

Funding

Sex and circuit-specific determinants of exercise-induced stress resilienceR01MH125898 · NIMH · UNIVERSITY OF COLORADO DENVER · PI BEN N GREENWOOD · 2022 to 2026
$3.0M
Nigrostriatal Dopaminergic Modulation of Fear ExtinctionR15MH114026 · NIMH · UNIVERSITY OF COLORADO DENVER · PI GREENWOOD, BEN N · 2017 to 2020
$933k
NIMH NIH HHS R01 MH125898NIMH NIH HHS R15 MH114026NIMH NIH HHS R15MH114026
6 · The paper itself

Abstract

rationaleExercise participation remains low despite clear benefits. Rats engage in voluntary wheel running (VWR) that follows distinct phases of acquisition, during which VWR escalates, and maintenance, during which VWR remains stable. Understanding mechanisms driving acquisition and maintenance of VWR could lead to novel strategies to promote exercise. The two phases of VWR resemble those that occur during operant conditioning and, therefore, might involve similar neural substrates. The dorsomedial (DMS) dorsal striatum (DS) supports the acquisition of operant conditioning, whereas the dorsolateral striatum (DLS) supports its maintenance.

objectivesHere we sought to characterize the roles of DS subregions in VWR. Females escalate VWR and operant conditioning faster than males. Thus, we also assessed for sex differences.

methodsTo determine the causal role of DS subregions in VWR, we pharmacologically inactivated the DMS or DLS of adult, male and female, Long-Evans rats during the two phases of VWR. The involvement of DA receptor 1 (D1)-expressing neurons in the DS was investigated by quantifying cfos mRNA within this neuronal population.

resultsWe observed that, in males, the DMS and DLS are critical for VWR exclusively during acquisition and maintenance, respectively. In females, the DMS is also critical only during acquisition, but the DLS contributes to VWR during both VWR phases. DLS D1 neurons could be an important driver of VWR escalation during acquisition.

conclusionsThe acquisition and maintenance of VWR involve unique neural substrates in the DS that vary by sex. Results reveal targets for sex-specific strategies to promote exercise.

Indexed as

Corpus StriatumMotor ActivityAnimalsFemaleMaleNeostriatumRatsRats, Long-EvansRNA, MessengerRNA, MessengerDopamineDorsal striatumDorsolateral striatumDorsomedial striatumExerciseHabitSex differencesWheel running

Identifiers

PMID36195731
PMCPMC9768838

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.