ArticleMolecular psychiatry2022
Clinical, environmental, and genetic risk factors for substance use disorders: characterizing combined effects across multiple cohorts.
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In one paragraph
Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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0cells of the map it votes in
22citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 26 citations in OpenAlex.
- Patterns, Predictors, and Correlates of Problematic Alcohol Use and Remission From Adolescence to Early Midlife.Alcohol, clinical & experimental research · 2026Article
- Regulatory mechanisms driven by functional 3'-UTR variants in alcohol use disorder and related traits.Genome biology · 2026Article
- Polygenic risk factors for comorbid diagnoses in individuals with substance use disorders: A phenome-wide survival analysis.Psychological medicine · 2026Article
- Are polygenic scores for psychiatric and substance use outcomes "ready" for clinical application? Current state and next steps.Psychiatric genetics · 2026Review
- The Relationship Between Serum Neurosteroids and Oxytocin Levels and Craving, Aggression and Emotion Regulation in Patients with Methamphetamine Use Disorder.Medical sciences (Basel, Switzerland) · 2026Observational
- Genetic nurture in intergenerational transmission of substance use.Nature communications · 2026Article
- Perceived partner substance use, genetic predispositions, and their associations with problematic alcohol use, emotional well-being, and relationship quality.Psychological medicine · 2026Article
- Substance Use and Suicide Attempts in Adolescents: A Comparative Analysis of Clinical and Psychosocial Risk Factors.Children (Basel, Switzerland) · 2026Article
- Polygenic Risk Factors for Comorbid Diagnoses in Individuals with Substance Use Disorders: A Phenome-Wide Survival Analysis.medRxiv : the preprint server for health sciences · 2025Article
- A Multivariate Genomic Investigation of the Externalizing Spectrum and Suicide Risk.medRxiv : the preprint server for health sciences · 2025Article
- Genetic, psychological, and environmental factors are uniquely associated with onset of alcohol use in the adolescent brain cognitive development (ABCD) study.Translational psychiatry · 2025Article
- Considerations for the application of polygenic scores to clinical care of individuals with substance use disorders.The Journal of clinical investigation · 2024Review
- Generalized genetic liability to substance use disorders.The Journal of clinical investigation · 2024Review
- Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort.JAMA psychiatry · 2024Article
- Digenic Analysis Finds Highly Interactive Genetic Variants Underlying Polygenic Traits.Medical research archives · 2023Article
- 5. Collaborative Study on the Genetics of Alcoholism: Functional genomics.Genes, brain, and behavior · 2023Review
- The collaborative study on the genetics of alcoholism: Sample and clinical data.Genes, brain, and behavior · 2023Review
- Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort.medRxiv : the preprint server for health sciences · 2023Article
- Editorial: Community series in neurobiological biomarkers for developing novel treatments of substance and non-substance addiction, volume II.Frontiers in psychiatry · 2023Article
- Article
Corrections and comments
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Authors and funding
29 authors at 12 institutions in 3 countries.
Peter B BarrDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA. peter.barr@downstate.edu.ORCID http://orcid.org/0000-0001-9321-657X
Morgan N DriverDepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA.ORCID http://orcid.org/0000-0001-6738-0667
Sally I-Chun KuoDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0002-6192-1001
Mallory StephensonVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Fazil AlievDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0001-8357-4699
Richard Karlsson LinnérDepartment of Economics, Leiden University, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-7839-2858
Jesse MarksBiostatistics and Epidemiology Division, RTI International, Research Triangle Park, Durham, NC, USA.ORCID http://orcid.org/0000-0002-8159-3594
Andrey P AnokhinDepartment of Psychiatry, School of Medicine, Washington University in St. Louis, St Louis, MO, USA.
Kathleen BucholzDepartment of Psychiatry, School of Medicine, Washington University in St. Louis, St Louis, MO, USA.
Grace ChanDepartment of Psychiatry, School of Medicine, University of Connecticut, Farmington, CT, USA.ORCID http://orcid.org/0000-0002-1257-6889
Howard J EdenbergDepartment of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0003-0344-9690
Alexis C EdwardsVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.ORCID http://orcid.org/0000-0002-4006-9710
Meredith W FrancisDepartment of Psychiatry, School of Medicine, Washington University in St. Louis, St Louis, MO, USA.
Dana B HancockBiostatistics and Epidemiology Division, RTI International, Research Triangle Park, Durham, NC, USA.ORCID http://orcid.org/0000-0003-2240-3604
K Paige HardenDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0002-1557-6737
Chella KamarajanDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.ORCID http://orcid.org/0000-0003-2291-6880
Jaakko KaprioInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-3716-2455
Sivan KinreichDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.ORCID http://orcid.org/0000-0001-6480-1622
John R KramerDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Samuel KupermanDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Antti LatvalaInstitute of Criminology and Legal Policy, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-5695-117X
Jacquelyn L MeyersDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.ORCID http://orcid.org/0000-0003-3863-8555
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3634-0747
Martin H PlaweckiDepartment of Psychiatry, School of Medicine, Indiana University, Indianapolis, IN, USA.
Bernice PorjeszDepartment of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Richard J RoseDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Marc A SchuckitDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Jessica E SalvatoreDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0001-5504-5087
Danielle M DickDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0002-1636-893X
SUNY Downstate Health Sciences University · USRutgers, The State University of New Jersey · USUniversity of Iowa · USVirginia Commonwealth University · USWashington University in St. Louis · USIndiana University – Purdue University Indianapolis · USRTI International · USUniversity of California San Diego · USUniversity of Helsinki · FIIndiana University Bloomington · USLeiden University · NLThe University of Texas at Austin · US
Funding
Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JESSICA E SALVATORE · 1989 to 2026
$162.7MWave IV Data CollectionP01HD031921 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 1994 to 2020
$86.1MNational Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VII Core ProjectU01AG071448 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Allison E Aiello, Lauren M Gaydosh · 2021 to 2026
$40.2MProject 5 - Genetic architecture of alcohol use disorder using cross-trait genetic correlations and public next-generation sequencing studiesP50AA022537 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MICHAEL F MILES · 2014 to 2026
$19.6MNational Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Cognition and Early Risk Factors for Dementia ProjectU01AG071450 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AIELLO, ALLISON E, HUMMER, ROBERT A · 2021 to 2025
$16.2MThe development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6MUsing the Genetic Architecture of Substance Use Disorders to Advance Gene Identification and Understanding of Pathways of RiskR01DA050721 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DANIELLE M DICK · 2020 to 2026
$3.9MIntegrating Epigenomics in Human Brain and Genomics of Nicotine DependenceR01DA042090 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI HANCOCK, DANA B · 2016 to 2020
$3.5MPathways to Alcohol Use Disorders in ALSPAC: A Genetic-Developmental StudyR01AA018333 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M, KENDLER, KENNETH SEEDMAN · 2010 to 2014
$2.8MTwin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3MMedical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_17228Medical Research Council MC_PC_19009Medical Research Council MC_QA137853NIAAA NIH HHS K02 AA018755NIAAA NIH HHS P50 AA022537NIAAA NIH HHS R01 AA015416NIAAA NIH HHS R01 AA018333NIAAA NIH HHS U10 AA008401NIA NIH HHS U01 AG071448NIA NIH HHS U01 AG071450NICHD NIH HHS P01 HD031921NIDA NIH HHS R01 DA042090NIDA NIH HHS R01 DA050721Wellcome Trust
Abstract
Substance use disorders (SUDs) incur serious social and personal costs. The risk for SUDs is complex, with risk factors ranging from social conditions to individual genetic variation. We examined whether models that include a clinical/environmental risk index (CERI) and polygenic scores (PGS) are able to identify individuals at increased risk of SUD in young adulthood across four longitudinal cohorts for a combined sample of N = 15,134. Our analyses included participants of European (N
Indexed as
AlcoholismSubstance-Related DisordersTobacco Use DisorderAdultAlcohol DrinkingHumansRisk FactorsYoung Adult
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