Evidence map›Paper›PMID 36195553›Full record

ArticleChemphyschem : a European journal of chemical physics and physical chemistry2023

Exploring the Potential of Multinuclear Solid-State

Patrick M J Szell, Zainab Rehman, Ben P Tatman, Leslie P Hughes, Helen Blade, Steven P Brown

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Chemphyschem : a European journal of chemical physics and physical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Exploring the Potential of Multinuclear Solid-StateChemphyschem : a European journal of chemical physics and physical chemistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Patrick M J SzellDepartment of Physics, University of Warwick, Coventry, CV4 7AL, UK.
Zainab RehmanDepartment of Physics, University of Warwick, Coventry, CV4 7AL, UK.
Ben P TatmanDepartment of Physics, University of Warwick, Coventry, CV4 7AL, UK.
Leslie P HughesOral Product Development Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, SK10 2NA, UK.
Helen BladeOral Product Development Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, SK10 2NA, UK.
Steven P BrownDepartment of Physics, University of Warwick, Coventry, CV4 7AL, UK.ORCID 0000-0003-2069-8496
University of Warwick · GBAstraZeneca (United Kingdom) · GB

Funding

Advantage West Midlands (AWM)AstraZeneca KTP11570BBSRC EP/T015063/1Birmingham Science City Advanced Materials Projects 1 and 2BrukerEPSRCEuropean Regional Development Fund (ERDF)Innovate UKMillburn House Magnetic Resonance LaboratoryPfizerUK High-Field Solid-State NMR FacilityUniversity of WarwickWarwick Centre for Doctoral Training in Analytical ScienceWRAP, the Warwick Research Archive Portal
6 · The paper itself

Abstract

Crystallographic disorder, whether static or dynamic, can be detrimental to the physical and chemical stability, ease of crystallization and dissolution rate of an active pharmaceutical ingredient. Disorder can result in a loss of manufacturing control leading to batch-to-batch variability and can lengthen the process of structural characterization. The range of NMR active nuclei makes solid-state NMR a unique technique for gaining nucleus-specific information about crystallographic disorder. Here, we explore the use of high-field

Indexed as

ChloridesMagnetic Resonance ImagingHumansMagnetic Resonance SpectroscopyPharmaceutical PreparationsChloridesPharmaceutical Preparationscrystallographic disorderdensity functional theoryNMRpharmaceuticalsX-ray crystallography

Identifiers

PMID36195553
PMCPMC10099218
OpenAlexW4301372705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.