Evidence map›Paper›PMID 36195283›Full record

ReviewJournal of advanced research2023

Trichoderma species from plant and soil: An excellent resource for biosynthesis of terpenoids with versatile bioactivities.

Bingke Bai, Chang Liu, Chengzhong Zhang, Xuhui He, Hongrui Wang, Wei Peng, Chengjian Zheng

Open access · goldAbstract readReview
In one paragraph

Review in Journal of advanced research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 47 citations in OpenAlex.

  1. Plant signaling & behavior · 2026
    Review
  2. Article
  3. Confrontations betweenApplied and environmental microbiology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Impact ofJournal of fungi (Basel, Switzerland) · 2024
    Article
  12. Chemistry and biology of marine-derived Trichoderma metabolites.Natural products and bioprospecting · 2024
    Review
  13. Identification and Characterization of a Plant Endophytic FungusJournal of fungi (Basel, Switzerland) · 2024
    Article
  14. Conditions for CaCOGlobal challenges (Hoboken, NJ) · 2024
    Article
  15. Article
  16. Journal of fungi (Basel, Switzerland) · 2023
    Review
  17. Light-Induced Changes in Secondary Metabolite Production ofJournal of fungi (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bingke BaiFaculty of Pharmacy, Naval Medical University, Shanghai 200433, PR China.
Chang LiuFaculty of Pharmacy, Naval Medical University, Shanghai 200433, PR China.
Chengzhong ZhangFaculty of Pharmacy, Naval Medical University, Shanghai 200433, PR China.
Xuhui HeFaculty of Pharmacy, Naval Medical University, Shanghai 200433, PR China.
Hongrui WangFaculty of Pharmacy, Naval Medical University, Shanghai 200433, PR China.
Wei PengState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China. Electronic address: pengwei@cdutcm.edu.cn.
Chengjian ZhengFaculty of Pharmacy, Naval Medical University, Shanghai 200433, PR China. Electronic address: cjzheng1984@126.com.
Chengdu University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTrichoderma species are rich source of bioactive secondary metabolites. In the past decades, a series of secondary metabolites were reported from different Trichoderma fungi, among which terpenoids possessing versatile structural diversities and extensive pharmacological activities are one of the particularly important categories. AIM OF REVIEW: The review aims to summarize the terpenoids isolated from Trichoderma species regarding their structural diversities, biological activities, and promising biosynthetic potentials. KEY SCIENTIFIC CONCEPTS OF REVIEW: So far, a total of 253 terpenoids, including 202 sesquiterpenes, 48 diterpenes, 2 monoterpenes and 1 meroterpenoid, were isolated and identified from Trichoderma species between 1948 and 2022. Pharmacological investigations of Trichoderma terpenoids mainly focused on their antibacterial activities, antifungal activities, inhibitory activities on marine plankton species and cytotoxic activities, indicating that Trichoderma species are important microbial agents for drug discovery and environmentally friendly agrochemicals development. Intriguing chemistry and enzymology involved in the biosynthesis of Trichoderma terpenoids were also presented to facilitate further precise genome mining-guided novel structure discovery. Taken together, the abundance of novel skeletons, bioactivities and biosynthetic potentials presents new opportunities for drug and agrochemicals discovery, genome mining and enzymology exploration from Trichoderma species. The work will provide references for the profound study of terpenoids derived from Trichoderma, and facilitate further studies on Trichoderma species in the areas of chemistry, medicine, agriculture and microbiology.

Indexed as

SesquiterpenesTrichodermaAntifungal AgentsSoilTerpenesAntifungal AgentsSesquiterpenesSoilTerpenesBiosynthesisPharmacological activityStructural diversityTerpeneTrichoderma species

Identifiers

PMID36195283
PMCPMC10334134
OpenAlexW4298325714

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.