Evidence map›Paper›PMID 36195172›Full record

ReviewThe Journal of allergy and clinical immunology2023

Human natural killer cells: Form, function, and development.

Emily M Mace

Abstract readReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed.

  1. Effect of Heat-TreatedNutrients · 2024
    Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Sex Steroid Hormone Regulation of T-Cell Function and Antitumor Immunity.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Unconventional functions of natural killer cells in homeostasis and disease.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  16. Article
  17. Lymphocyte subpopulations and EEG asymmetry.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  18. Review
  19. Article
  20. Article

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Emily M MaceDivision of Allergy, Immunology and Rheumatology, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York. Electronic address: em3375@cumc.columbia.edu.

Funding

DEFINING THE ROLE OF CELL MIGRATION IN HUMAN NK CELL DIFFERENTIATIONR01AI137073 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MACE, EMILY MARGARET · 2018 to 2022
$2.0M
DETERMINING THE ROLE OF THE REPLICATIVE HELICASE IN HUMAN NK CELL DEVELOPMENTR01AI137275 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MACE, EMILY MARGARET · 2018 to 2022
$1.9M
NIAID NIH HHS R01 AI137073NIAID NIH HHS R01 AI137275
6 · The paper itself

Abstract

Human natural killer (NK) cells are innate lymphoid cells that mediate important effector functions in the control of viral infection and malignancy. Their ability to distinguish "self" from "nonself" and lyse virally infected and tumorigenic cells through germline-encoded receptors makes them important players in maintaining human health and a powerful tool for immunotherapeutic applications and fighting disease. This review introduces our current understanding of NK cell biology, including key facets of NK cell differentiation and the acquisition and execution of NK cell effector function. Further, it addresses the clinical relevance of NK cells in both primary immunodeficiency and immunotherapy. It is intended to provide an up-to-date and comprehensive overview of this important and interesting innate immune effector cell subset.

Indexed as

NeoplasmsVirus DiseasesHumansImmunity, InnateImmunotherapyKiller Cells, Naturalcytotoxicityinnate lymphoid cellsNatural killer cells

Identifiers

PMID36195172
PMCPMC9905317

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.