ArticleCurrent biology : CB2022
Orbitofrontal cortex populations are differentially recruited to support actions.
Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Reward contingency reorganizes lateral orbitofrontal cortex pyramidal neuron activity from reward-aligned to action-aligned during associative learning.Frontiers in cellular neuroscience · 2026Article
- Mediodorsal Thalamic Input to Striatum Contributes to Early Action Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Alcohol drinking is associated with greater calcium activity in mouse central amygdala dynorphin-expressing neurons.Progress in neuro-psychopharmacology & biological psychiatry · 2025Article
- The medial and lateral orbitofrontal cortex jointly represent the cognitive map of task space.Communications biology · 2025Article
- Action inflexibility and compulsive-like behavior accompany neurobiological alterations in the anterior orbitofrontal cortex and associated striatal nuclei.Scientific reports · 2025Article
- Functional specialization of medial and lateral orbitofrontal cortex in inferential decision-making.iScience · 2024Article
- Review
- Adolescents rats engage the orbitofrontal-striatal pathway differently than adults during impulsive actions.Scientific reports · 2024Article
- Chronic alcohol exposure alters action control via hyperactive premotor corticostriatal activity.Cell reports · 2023Article
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4 authors.
Funding
Abstract
The ability to use information from one's prior actions is necessary for decision-making. While orbitofrontal cortex (OFC) has been hypothesized as key for inferences made using cue and value-related information, whether OFC populations contribute to the use of information from volitional actions to guide behavior is not clear. Here, we used a self-paced lever-press hold-down task in which mice infer prior lever-press durations to guide subsequent action performance. We show that the activity of genetically identified lateral OFC (lOFC) subpopulations differentially instantiate current and prior action information during ongoing action execution. Transient state-dependent lOFC circuit disruptions of specified subpopulations reduced the encoding of ongoing press durations but did not disrupt the use of prior action information to guide future action performance. In contrast, a chronic functional loss of lOFC circuit activity resulted in increased reliance on recently executed lever-press durations and impaired contingency reversal, suggesting the recruitment of compensatory mechanisms that resulted in repetitive action control. Our results identify a novel role for lOFC in the integration of action information to guide adaptive behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.