ArticleThe journal of physical chemistry. B2022
The Effect of Time Resolution on Apparent Transition Path Times Observed in Single-Molecule Studies of Biomolecules.
Article in The journal of physical chemistry. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The significance of fuzzy boundaries of the barrier regions in single-molecule measurements of failed barrier crossing attempts.The Journal of chemical physics · 2024Article
- Article
- Waiting Time Distributions in Hybrid Models of Motor-Bead Assays: A Concept and Tool for Inference.International journal of molecular sciences · 2023Article
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4 authors.
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Abstract
Single-molecule experiments have now achieved a time resolution allowing observation of transition paths, the brief trajectory segments where the molecule undergoing an unfolding or folding transition enters the energetically or entropically unfavorable barrier region from the folded/unfolded side and exits to the unfolded/folded side, thereby completing the transition. This resolution, however, is yet insufficient to identify the precise entrance/exit events that mark the beginning and the end of a transition path: the nature of the diffusive dynamics is such that a molecular trajectory will recross the boundary between the barrier region and the folded/unfolded state, multiple times, at a time scale much shorter than that of the typical experimental resolution. Here we use theory and Brownian dynamics simulations to show that, as a result of such recrossings, the apparent transition path times are generally longer than the true ones. We quantify this effect using a simple model where the observed dynamics is a moving average of the true dynamics and discuss experimental implications of our results.
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