Evidence map›Paper›PMID 36194691›Full record

ArticleACS chemical biology2022

Photoswitchable Isoprenoid Lipids Enable Optical Control of Peptide Lipidation.

Johannes Morstein, Taysir Bader, Ariana L Cardillo, Julian Schackmann, Sudhat Ashok, James L Hougland, Christine A Hrycyna, Dirk H Trauner, Mark D Distefano

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Synthetic Lipid Biology.Chemical reviews · 2025
    Review
  4. Article
  5. Article
  6. Promiscuous Enzymes for Residue-Specific Peptide and Protein Late-Stage Functionalization.Chembiochem : a European journal of chemical biology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Johannes MorsteinDepartment of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California, San Francisco, California 94158, United States.ORCID 0000-0002-6940-288X
Taysir BaderDepartment of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0002-0682-1905
Ariana L CardilloDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-9770-2177
Julian SchackmannDepartment of Chemistry, New York University, New York, New York 10003, United States.
Sudhat AshokDepartment of Chemistry, Syracuse University, Syracuse, New York 13244, United States.
James L HouglandDepartment of Chemistry, Syracuse University, Syracuse, New York 13244, United States.ORCID 0000-0003-0444-1017
Christine A HrycynaDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0001-9881-2063
Dirk H TraunerDepartment of Chemistry, New York University, New York, New York 10003, United States.ORCID 0000-0002-6782-6056
Mark D DistefanoDepartment of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0002-2872-0259
New York University · USPurdue University West Lafayette · USUniversity of Minnesota · USHoward Hughes Medical Institute · USLiving Systems (United States) · USSyracuse University · US

Funding

Transport Cycle and Inhibition of Human Na+-dicarboxylate Cotransporter NaDC3R01NS108151 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DANENG WANG · 2018 to 2026
$4.1M
Chemical Approaches for Exploring Protein Prenylation in Living CellsR35GM141853 · NIGMS · UNIVERSITY OF MINNESOTA · PI MARK D DISTEFANO · 2021 to 2026
$2.4M
Determining the scope of prenylatable protein sequencesR01GM132606 · NIGMS · UNIVERSITY OF GEORGIA · PI KANNAN, NATARAJAN, SCHMIDT, WALTER K · 2019 to 2022
$1.6M
Lipid-based Cancer TherapeuticsK00CA253758 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MORSTEIN, JOHANNES · 2021 to 2022
$169k
NCI NIH HHS K00 CA253758NIGMS NIH HHS R01 GM132606NIGMS NIH HHS R35 GM141853NINDS NIH HHS R01 NS108151
6 · The paper itself

Abstract

Photoswitchable lipids have emerged as attractive tools for the optical control of lipid bioactivity, metabolism, and biophysical properties. Their design is typically based on the incorporation of an azobenzene photoswitch into the hydrophobic lipid tail, which can be switched between its

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsFarnesyltranstransferaseLipidsMembrane ProteinsMetalloendopeptidasesPeptidesPheromonesProtein PrenylationSphingolipidsTerpenesFarnesyltranstransferaseLipidsMembrane ProteinsMetalloendopeptidasesPeptidesPheromonesSaccharomyces cerevisiae ProteinsSphingolipidsSTE24 protein, S cerevisiaeTerpenes

Identifiers

PMID36194691
PMCPMC9799063
OpenAlexW4301182919

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.