Evidence map›Paper›PMID 36194256›Full record

Trial reportEuropean journal of pediatrics2022

Neurodevelopmental outcomes of very preterm infants who received cord milking at birth: a randomized controlled trial.

Walid El-Naggar, Douglas McMillan, Arif Hussain, Anthony Armson, Linda Dodds, Andrew Warren, Robin Whyte, Michael Vincer, C David Simpson

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01487187 (The Effect of Umbilical Cord Milking on Hemodynamic Status of Preterm Infants), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01487187 naunknown statusnot on this map

The Effect of Umbilical Cord Milking on Hemodynamic Status of Preterm Infants: a Randomized Controlled Trial

TypeinterventionalSponsorWalid El-NaggarRan2011 to 2018Enrolled73ConditionsPreterm InfantsArmsMilking the umbilical cord at birth, immediate umbilical cord clamping
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Walid El-NaggarDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, IWK Health Centre, Dalhousie University, 5850/5980 University Ave., PO Box 9700, Halifax, NS, B3K 6R8, Canada. walid.el-naggar@iwk.nshealth.ca.
Douglas McMillanDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, IWK Health Centre, Dalhousie University, 5850/5980 University Ave., PO Box 9700, Halifax, NS, B3K 6R8, Canada.
Arif HussainDivision of Cardiology, Department of Pediatrics, Dalhousie University, Halifax, Canada.
Anthony ArmsonDepartment of Obstetrics & Gynecology, Dalhousie University, Halifax, Canada.
Linda DoddsPerinatal Epidemiology Research Unit, Departments of Obstetrics & Gynecology and Pediatrics, Dalhousie University, Halifax, Canada.
Andrew WarrenDivision of Cardiology, Department of Pediatrics, Dalhousie University, Halifax, Canada.
Robin WhyteDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, IWK Health Centre, Dalhousie University, 5850/5980 University Ave., PO Box 9700, Halifax, NS, B3K 6R8, Canada.
Michael VincerDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, IWK Health Centre, Dalhousie University, 5850/5980 University Ave., PO Box 9700, Halifax, NS, B3K 6R8, Canada.
C David SimpsonDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, IWK Health Centre, Dalhousie University, 5850/5980 University Ave., PO Box 9700, Halifax, NS, B3K 6R8, Canada.
Dalhousie University · CAIzaak Walton Killam Health Centre · CA

Funding

IWK Research Foundation 1008052Nova Scotia Health Research Foundation Nova Scotia Health Research Foundation (PSO-EST-2013-9023 EGMS 1813)
6 · The paper itself

Abstract

Umbilical cord milking improves postnatal adaptation and short-term outcomes of very preterm infants compared to early cord clamping. Little is known about the impact of umbilical cord milking on long-term neurodevelopmental outcomes. The objective of this study is to compare the effects of intact umbilical cord milking (UCM) vs. early cord clamping (ECC) at birth on neurodevelopmental outcomes at 36 months' corrected age. Preterm infants < 31 weeks' gestation who were randomized at birth to receive three time milking of their attached cord or ECC (< 10 s) were evaluated at 36 months' corrected age. Neurodevelopmental outcomes were assessed by blinded examiners using Bayley Scales of Infant and Toddler Development (version III). Analysis was by intention to treat. Out of the 73 infants included in the original trial, 2 died and 65 (92%) infants were evaluated at 36 months' corrected age. Patient characteristics and short-term outcomes were similar in both study groups. There were no significant differences in the median cognitive, motor or language scores or in the rates of cerebral palsy, developmental impairment, deafness, or blindness between study groups.

conclusionNeurodevelopmental outcomes at 36 months' corrected age of very preterm infants who received UCM were not shown to be significantly different from those who received ECC at birth.

trial registrationClinicalTrials.gov: NCT01487187 What is Known: • Compared to early cord clamping, umbilical cord milking improves postnatal adaptation and short-term outcomes of very preterm infants compared to early cord clamping. • Little is known about the impact of umbilical cord milking on neurodevelopmental outcomes. WHAT IS NEW: • Neurodevelopmental outcomes at 3 years of age were not significantly different in very preterm infants who received cord milking vs. those who received early cord clamping at birth.

Indexed as

Infant, PrematureInfant, Premature, DiseasesConstrictionFemaleFetal Growth RetardationHumansInfantInfant, NewbornInfant, Very Low Birth WeightUmbilical CordEarly cord clampingLong-term neurodevelopmental outcomesPreterm infantsUmbilical cord milking

Identifiers

PMID36194256
OpenAlexW4301391788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.