Evidence map›Paper›PMID 36194022›Full record

ArticleInfection and immunity2022

Pathogenic

Wearn-Xin Yee, Christoph M Tang, Hayley Lavender

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Mechanisms by which Factor H protectsFrontiers in immunology · 2024
    Article
  3. The human factor H protein family - an update.Frontiers in immunology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Wearn-Xin YeeSir William Dunn School of Pathology, University of Oxfordgrid.4991.5, Oxford, United Kingdom.
Christoph M TangSir William Dunn School of Pathology, University of Oxfordgrid.4991.5, Oxford, United Kingdom.ORCID 0000-0001-8366-3245
Hayley LavenderSir William Dunn School of Pathology, University of Oxfordgrid.4991.5, Oxford, United Kingdom.ORCID 0000-0001-9996-8107
University of Oxford · GB

Funding

Wellcome Trust 102908/Z/13/Z
6 · The paper itself

Abstract

Neisseria meningitidis and Neisseria gonorrhoeae are important human pathogens that have evolved to bind the major negative regulator of the complement system, complement factor H (CFH). However, little is known about the interaction of pathogens with CFH-related proteins (CFHRs) which are structurally similar to CFH but lack the main complement regulatory domains found in CFH. Insights into the role of CFHRs have been hampered by a lack of specific reagents. We generated a panel of CFHR-specific monoclonal antibodies and demonstrated that CFHR5 was bound by both pathogenic

Indexed as

Neisseria meningitidisPorinsAntibodies, MonoclonalBacterial Outer Membrane ProteinsComplement Factor HHumansLipopolysaccharidesNeisseriaNeisseria gonorrhoeaeAntibodies, MonoclonalBacterial Outer Membrane ProteinsComplement Factor HLipopolysaccharidesPorinsCFHCFHRcomplementNeisseria gonorrhoeaeNeisseria meningitidis

Identifiers

PMID36194022
PMCPMC9584296
OpenAlexW4301392866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.