Molecular Docking Studies, Synthesis and Biological Evaluation of Substituted Pyrimidine-2,4-diamines as Inhibitors of Plasmodium falciparum Dihydrofolate Reductase.
Article in ChemMedChem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Khonzisizwe SomandiMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, PO, WITS, 2050, South Africa.ORCID 0000-0001-5652-5533
Tswene D SeanegoMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, PO, WITS, 2050, South Africa.ORCID 0000-0001-8871-5251
Tebogo Dlamini Née MolatsaneMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, PO, WITS, 2050, South Africa.
Matthew MareeMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, PO, WITS, 2050, South Africa.ORCID 0000-0002-8918-7267
Charles B de KoningMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, PO, WITS, 2050, South Africa.
Jarunee VanichtanankulNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Thailand Science Park, Pathumthani, 12120, Thailand.ORCID 0000-0003-3431-1467
Roonglawan RattanajakNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Thailand Science Park, Pathumthani, 12120, Thailand.ORCID 0000-0003-3721-235X
Thanaya SaeyangNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Thailand Science Park, Pathumthani, 12120, Thailand.ORCID 0000-0002-7819-8657
Yongyuth YuthavongNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Thailand Science Park, Pathumthani, 12120, Thailand.ORCID 0000-0002-3582-8401
Sumalee KamchonwongpaisanNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Thailand Science Park, Pathumthani, 12120, Thailand.ORCID 0000-0002-4723-5232
Amanda L RousseauMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, PO, WITS, 2050, South Africa.ORCID 0000-0002-9339-1797
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
A series of 5-[(phenethylamino)methyl]pyrimidine-2,4-diamines were assessed in silico as potential inhibitors of Plasmodium falciparum dihydrofolate reductase (PfDHFR), synthesised and tested for inhibitory activity against PfDHFR in vitro. The compounds displayed promising inhibitory activity against both wild-type (K
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.