Evidence map›Paper›PMID 36193862›Full record

ReviewHead & neck2023

Role of sentinel lymph node biopsy for oral squamous cell carcinoma: Current evidence and future challenges.

Sophie S Jang, Morgan E Davis, David R Vera, Stephen Y Lai, Theresa W Guo

Open access · greenAbstract readReview
In one paragraph

Review in Head & neck, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Siglec expression in sentinel lymph nodes in patients with oral squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  3. [Contrast-enhanced CT-based habitat radiomics for analyzing the predictive capability for oral squamous cell carcinoma].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026
    Article
  4. Article
  5. Review
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  11. Standardized treatment of oral cancer under the guidance of clinical practice guidelines of National Comprehensive Cancer Network.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2024
    Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sophie S JangDepartment of Otolaryngology - Head and Neck Surgery, University of California, San Diego, La Jolla, California, USA.ORCID https://orcid.org/0000-0002-8074-5058
Morgan E DavisDepartment of Otolaryngology - Head and Neck Surgery, University of California, San Diego, La Jolla, California, USA.
David R VeraDepartment of Radiology, University of California, San Diego, La Jolla, California, USA.
Stephen Y LaiDepartment of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0001-8301-7286
Theresa W GuoDepartment of Otolaryngology - Head and Neck Surgery, University of California, San Diego, La Jolla, California, USA.ORCID https://orcid.org/0000-0002-1689-3275
University of California San Diego · USThe University of Texas MD Anderson Cancer Center · US

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9M
Otolaryngology Training in Immunology, Virology and Molecular BiologyR25DC020173 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joseph A Califano · 2022 to 2026
$1.4M
NCI NIH HHS P30 CA023100NIDCD NIH HHS R25 DC020173
6 · The paper itself

Abstract

Sentinel lymph node biopsy (SLNB) has been used across oncological specialties for prognostication, staging, and identification of occult nodal metastasis. Recent studies demonstrated the potential clinical utility of SLNB in oral cavity squamous cell carcinoma (OCSCC). Elective neck dissection is the current standard of care in early management of OCSCC with depth of invasion greater than 2-4 mm; however, majority of patients ultimately do not have nodal disease on final pathology. SLNB is an alternative procedure widely adopted in early cancer management in many oncological subspecialities. Several considerations such as depth of invasion, nodal mapping, histopathology methods, operator variability, postoperative complications, and advancement in preoperative and intraoperative imaging technology can guide the appropriate application to SLNB in OCSCC. The aim of this review is to discuss the current evidence for SLNB in the treatment of early stage OCSCC, imaging technologies that support SLNB procedures, and studies that are currently underway.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsHumansLymphatic MetastasisLymph NodesNeoplasm StagingSentinel Lymph Node BiopsySquamous Cell Carcinoma of Head and Neckoral squamous cell carcinomasentinel lymph node biopsy

Identifiers

PMID36193862
PMCPMC11081060
OpenAlexW4301392044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.