Evidence map›Paper›PMID 36193770›Full record

ArticleThoracic cancer2022

Protein tyrosine phosphatase PTPL1 suppresses lung cancer through Src/ERK/YAP1 signaling.

Jing Wang, Shuanghui Li, Xiujuan Zhang, Ning Zhu, Ruzetuoheti Yiminniyaze, Liang Dong, Chengwei Li, Wumaier Gulinuer, Jingwen Xia, Jing Li and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thoracic cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Jing WangDepartment of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Shuanghui LiDepartment of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Xiujuan ZhangDepartment of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Ning ZhuDepartment of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Ruzetuoheti YiminniyazeDepartment of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-9403-9613
Liang DongDepartment of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Chengwei LiDepartment of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Wumaier GulinuerDepartment of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Jingwen XiaDepartment of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Jing LiDepartment of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Daibing ZhouDepartment of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-7723-1470
Xinning LiuDepartment of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Youzhi ZhangDepartment of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Yuanyuan ZhangDepartment of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Shengqing LiDepartment of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-0570-2656
Fudan University · CNHuashan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo reveal the function of protein tyrosine phosphatase-L1 (PTPL1) in lung adenocarcinoma.

methodsLung cancer cell lines were transfected with short hairpin RNA against PTPL1 (shPTPL1 group) or negative control (shmock group). Quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting were used to verify the transfection efficacy. Cell proliferation was analyzed by ethynyldeoxyuridine (EdU), Cell counting kit 8 (CCK8), and colony formation assay after PTPL1 or PTPL1 and yes-associated protein (YAP1) knockdown. The effect of PTPL1 on tumor growth was examined in a xenograft lung cancer model.

resultsPTPL1 was downregulated in various types of lung cancer cell lines. The EdU, CCK8, colony formation assays and investigation using a xenograft lung cancer model indicated that PTPL1 knockdown increased the proliferation of lung cancer cells. Mechanistically, PTPL1 knockdown induced the activation of the Proto-oncogene tyrosine-protein kinase SRC (Src)/Extracellular regulated MAP kinase (ERK) pathway and thereby promoted yes-associated protein (YAP1) nuclear translocation and activation.

conclusionsIn our study, PTPL1 played a crucial suppressive role in the pathogenesis of lung cancer potentially through counteracting the Src/ERK/YAP1 pathway.

Indexed as

Adenocarcinoma of LungLung NeoplasmsCell Line, TumorCell ProliferationHumansProtein Tyrosine Phosphatase, Non-Receptor Type 13Receptor Protein-Tyrosine KinasesSignal TransductionYAP-Signaling ProteinsProtein Tyrosine Phosphatase, Non-Receptor Type 13PTPN13 protein, humanReceptor Protein-Tyrosine KinasesYAP-Signaling Proteinsnon-small cell lung cancerproliferationPTPL1

Identifiers

PMID36193770
PMCPMC9626330
OpenAlexW4301391519

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.