Evidence map›Paper›PMID 36193708›Full record

ReviewResearch report (Health Effects Institute)2022

Assessing Adverse Health Effects of Long-Term Exposure to Low Levels of Ambient Air Pollution: Implementation of Causal Inference Methods.

F Dominici, A Zanobetti, J Schwartz, D Braun, B Sabath, X Wu

Abstract readReview
In one paragraph

Review in Research report (Health Effects Institute), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Effects of the inhaled dose of air pollution on health: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  2. Long-Term Exposure to Low-LevelEnvironmental health perspectives · 2023
    Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Low-Level PMInternational journal of environmental research and public health · 2025
    Article
  11. Article
  12. Long-term exposure to ambient PMEnvironmental epidemiology (Philadelphia, Pa.) · 2025
    Article
  13. Methods for Estimating the Exposure-Response Curve to Inform the New Safety Standards for Fine Particulate Matter.Journal of the Royal Statistical Society. Series A, (Statistics in Society) · 2025
    Article
  14. Article
  15. Article
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

F DominiciHarvard T.H. Chan School of Public Health, Boston, Massachusetts.
A ZanobettiHarvard T.H. Chan School of Public Health, Boston, Massachusetts.
J SchwartzHarvard T.H. Chan School of Public Health, Boston, Massachusetts.
D BraunHarvard T.H. Chan School of Public Health, Boston, Massachusetts.
B SabathHarvard T.H. Chan School of Public Health, Boston, Massachusetts.
X WuHarvard T.H. Chan School of Public Health, Boston, Massachusetts.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This report provides a final summary of the principal findings and key conclusions of a study supported by an HEI grant aimed at "Assessing Adverse Health Effects of Long-Term Exposure to Low Levels of Ambient Air Pollution." It is the second and final report on this topic. The study was designed to advance four critical areas of inquiry and methods development. First, it focused on predicting short- and long-term exposures to ambient fine particulate matter (PM Considering our (1) massive study population, (2) numerous sensitivity analyses, and (3) transparent assessment of covariate balance indicating the quality of causal inference for simulating randomized experiments, we conclude that conditionally on the required assumptions for causal inference, our results collectively indicate that long-term PM Our work provides comprehensive evidence of associations between exposures to PM For the period 2000-2016, we found that all statistical approaches led to consistent results: a 10-μg/m Comparing the results from multiple and single pollutant models, we found that adjusting for the other two pollutants slightly attenuated the causal effects of PM We found evidence of a harmful causal relationship between mortality and long-term PM There is, in general, a harmful causal impact of long-term NO The ERCs of long-term O institutions, including those that support the Health Effects Institute; therefore, it may not reflect the views or policies of these parties, and no endorsement by them should be inferred. A list of abbreviations and other terms appears at the end of this volume.

Indexed as

Air PollutantsAir PollutionOzoneAgedEnvironmental ExposureHumansIatrogenic DiseaseMedicareNitrogen DioxideParticulate MatterReproducibility of ResultsUnited StatesAir PollutantsNitrogen DioxideOzoneParticulate Matter

Identifiers

PMID36193708
PMCPMC9530797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.