Evidence map›Paper›PMID 36193598›Full record

ArticleNuclear medicine and biology

Solid phase radiosynthesis of an olaparib derivative using 4-[

Jinbin Xu, Huaping Chen, Buck E Rogers, John A Katzenellenbogen, Dong Zhou

Open access · greenAbstract read
In one paragraph

Article in Nuclear medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jinbin XuDepartment of Radiology, School of Medicine, Washington University in Saint Louis, Saint Louis, MO 63110, USA. Electronic address: jinbinxu@wustl.edu.
Huaping ChenDepartment of Radiology, School of Medicine, Washington University in Saint Louis, Saint Louis, MO 63110, USA.
Buck E RogersRadiation Oncology, School of Medicine, Washington University in Saint Louis, Saint Louis, MO 63110, USA.
John A KatzenellenbogenDepartment of Chemistry and Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Dong ZhouDepartment of Radiology, School of Medicine, Washington University in Saint Louis, Saint Louis, MO 63110, USA. Electronic address: zhoud@wustl.edu.
University of Illinois Urbana-Champaign · USWashington University in St. Louis · US

Funding

RATIONAL DESIGN OF BREAST TUMOR IMAGING AGENTSR01CA025836 · NCI · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI KATZENELLENBOGEN, JOHN A. · 1985 to 2017
$4.2M
Dissect the mechanisms of selective regional vulnerability in Lewy Body Dementias via comparative snRNA-seq analysisR01NS123571 · NINDS · WASHINGTON UNIVERSITY · PI XU, JINBIN, ZHAO, GUOYAN · 2021 to 2025
$3.6M
Imaging and Targeted Auger Radiotherapy of High-Grade GliomaR01EB029752 · NIBIB · WASHINGTON UNIVERSITY · PI GARBOW, JOEL RICHARD, ROGERS, BUCK E. · 2020 to 2023
$3.1M
POSTMORTEM VALIDATION OF BIOMARKERS FOR IMAGING PARKINSON DISEASER01NS092865 · NINDS · WASHINGTON UNIVERSITY · PI XU, JINBIN · 2016 to 2020
$1.7M
Optimization of imaging mass cytometry, a single-cell spatial proteomics technology, for the study of Alzheimer diseaseR21AG077643 · NIA · WASHINGTON UNIVERSITY · PI XU, JINBIN, ZHAO, GUOYAN · 2022 to 2022
$433k
Small Molecule GPCR Ligands for Oncologic ImagingR21EB028302 · NIBIB · WASHINGTON UNIVERSITY · PI ROGERS, BUCK E., XU, JINBIN · 2020 to 2021
$433k
Define molecular events driving selective neuronal death in multiple neurodegenerative diseases by snRNA-seqR03AG070474 · NIA · WASHINGTON UNIVERSITY · PI XU, JINBIN, ZHAO, GUOYAN · 2021 to 2022
$315k
DOPAMINE D1, D2, AND D3 RECEPTORS AS BIOMARKERS FOR IMAGING NIGROSTRIATAL NEURONSR03NS090214 · NINDS · WASHINGTON UNIVERSITY · PI XU, JINBIN · 2014 to 2015
$153k
NCI NIH HHS R01 CA025836NIA NIH HHS R03 AG070474NIA NIH HHS R21 AG077643NIBIB NIH HHS R01 EB029752NIBIB NIH HHS R21 EB028302NINDS NIH HHS R01 NS092865NINDS NIH HHS R01 NS123571NINDS NIH HHS R03 NS090214
6 · The paper itself

Abstract

introductionSolid-phase synthesis and conjugation reactions of acids and amines using coupling reagents are common in organic synthesis, but rare in

methodsFluoro-, bromo- and iodo-benzoic derivatives of olaparib were synthesized, and their PARP-1 affinities were measured using a recently developed cell culture-based competitive assay. To produce [

resultsThe best derivatives of olaparib were identified as compound 4, 7 and 8. [

conclusionsThis method is simple and efficient, having great potential for the synthesis of radiopharmaceuticals starting from [

Indexed as

Poly(ADP-ribose) Polymerase InhibitorsProstatic NeoplasmsAnimalsHeterograftsHumansMalePhthalazinesPiperazinesPoly (ADP-Ribose) Polymerase-1Positron-Emission TomographyRadiopharmaceuticalsTissue DistributionolaparibPhthalazinesPiperazinesPoly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) Polymerase InhibitorsRadiopharmaceuticals4-[(18)F]fluorobenzoic acidOlaparibPARP-1PET imagingSolid phase radiosynthesis

Identifiers

PMID36193598
PMCPMC10061341
OpenAlexW4297140904

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.