Evidence map›Paper›PMID 36193331›Full record

ArticleCase reports in infectious diseases2022

Mendelian Susceptibility to Mycobacterial Diseases (MSMD) in a 13-Year-Old Ethiopian Girl with Autosomal Dominant Interferon Gamma Receptor 1(IFN-

Netsanet Azene Gebeyehu, Solomie Jebessa Deribessa, Freeman Alexandra, Messay Tesfaye Demissie, W Mihretu Gebre, Aklilu Melaku Gebremariam, Dagmawit Mitiku Engliz, Tizita Yosef Kidane, Lidya Million Bekele, Abate Yeshidinber Weldetsadik

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PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Netsanet Azene GebeyehuDepartment of Dermatology and Venereology, Addis Ababa University College of Health Sciences, Addis Ababa, Ethiopia.
Solomie Jebessa DeribessaPediatrics Infectious Disease Specialist, Department of Pediatrics and Child Health, St.Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.ORCID https://orcid.org/0000-0002-7391-9419
Freeman AlexandraPrimary Immune Deficiency Clinic Laboratory of Clinical Immunology and Microbiology NIAID, NIH, North Bethesda, MD, USA.
Messay Tesfaye DemissieDermatovenerologist, Pediatric Dermatology Fellow, Addis Ababa University College of Health Sciences, Addis Ababa, Ethiopia.
W Mihretu GebreDermatovenerologist, Photoallergologist, Addis Ababa University College of Health Sciences, Addis Ababa, Ethiopia.
Aklilu Melaku GebremariamDermatovenerologist, Dermatopathologist, Addis Ababa University College of Health Sciences, Addis Ababa, Ethiopia.
Dagmawit Mitiku EnglizDermatovenerologist, Debre Birhan Specialized Hospital, Debre Birhan, Ethiopia.
Tizita Yosef KidaneDermatovenerologist, Dermatosurgeon, Addis Ababa University College of Health Sciences, Addis Ababa, Ethiopia.
Lidya Million BekelePediatrics Resident, Department of Pediatrics and Child Health, St.Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Abate Yeshidinber WeldetsadikDivision of Pulmonary and Critical Care, Department of Pediatrics and Child Health, St.Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Addis Ababa University · ETSt. Paul's Hospital Millennium Medical College · ETDebre Berhan University · ETImmune Deficiency Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Mendelian susceptibility to mycobacterial diseases (MSMD) is an inborn error of immunity categorized as defects in intrinsic and innate immunity. MSMD is characterized by vulnerability to less virulent mycobacteria, such as Case: A 13-year-old female patient had multiple hospital visits since the age of 6 months. The most striking diagnosis was repeated mycobacterial infections. She had Conclusion: To the authors' knowledge, this is the first case report of Mendelian susceptibility to mycobacterial diseases secondary to interferon gamma receptor 1(IFNG-R1) defect in Ethiopia. Although it has been immensely challenging, our multidisciplinary team has learned a lot from the clinical presentation, diagnosis, and management of this child.

Identifiers

PMID36193331
PMCPMC9525766
OpenAlexW4297018383

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.