Evidence map›Paper›PMID 36193159›Full record

ArticleMatrix biology plus2022

Extracellular Matrix Profiling and Disease Modelling in Engineered Vascular Smooth Muscle Cell Tissues.

Ella Reed, Adam Fellows, Ruifang Lu, Marieke Rienks, Lukas Schmidt, Xiaoke Yin, Elisa Duregotti, Mona Brandt, Susanne Krasemann, Kristin Hartmann and 5 more

Open access · goldAbstract read
In one paragraph

Article in Matrix biology plus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Spatial Transcriptomics RevealsbioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Ella ReedKing's British Heart Foundation Centre, School of Cardiovascular and Metabolic Medicine and Sciences, London SE5 9NU, UK.
Adam FellowsKing's British Heart Foundation Centre, School of Cardiovascular and Metabolic Medicine and Sciences, London SE5 9NU, UK.
Ruifang LuKing's British Heart Foundation Centre, School of Cardiovascular and Metabolic Medicine and Sciences, London SE5 9NU, UK.
Marieke RienksKing's British Heart Foundation Centre, School of Cardiovascular and Metabolic Medicine and Sciences, London SE5 9NU, UK.
Lukas SchmidtKing's British Heart Foundation Centre, School of Cardiovascular and Metabolic Medicine and Sciences, London SE5 9NU, UK.
Xiaoke YinKing's British Heart Foundation Centre, School of Cardiovascular and Metabolic Medicine and Sciences, London SE5 9NU, UK.
Elisa DuregottiKing's British Heart Foundation Centre, School of Cardiovascular and Metabolic Medicine and Sciences, London SE5 9NU, UK.
Mona BrandtInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Susanne KrasemannInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Kristin HartmannInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Javier Barallobre-BarreiroKing's British Heart Foundation Centre, School of Cardiovascular and Metabolic Medicine and Sciences, London SE5 9NU, UK.
Owen AddisonCentre of Oral, Clinical & Translational Sciences, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, Guy's Hospital, London SE1 9RT, UK.
Friederike CuelloInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Arne HansenInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Manuel MayrKing's British Heart Foundation Centre, School of Cardiovascular and Metabolic Medicine and Sciences, London SE5 9NU, UK.
British Heart Foundation · GBUniversity Medical Center Hamburg-Eppendorf · DEGuy's Hospital · GBUniversität Hamburg · DE

Funding

British Heart Foundation RG/F/21/110053British Heart Foundation SP/19/4/34677
6 · The paper itself

Abstract

Aortic smooth muscle cells (SMCs) have an intrinsic role in regulating vessel homeostasis and pathological remodelling. In two-dimensional (2D) cell culture formats, however, SMCs are not embedded in their physiological extracellular matrix (ECM) environment. To overcome the limitations of conventional 2D SMC cultures, we established a 3D

Indexed as

2D, Two-dimensional3D cell culture3D, Three-dimensionalADAMTS, A disintegrin and metalloproteinase with thrombospondin motifsALKi, Activin-like kinase inhibitorCalcificationECMECM, Extracellular matrixEHT, Engineered heart tissueEVT, Engineered vascular smooth muscle cell tissueLC-MS/MS, Liquid chromatography with tandem mass spectrometryProteomicsSMC, Smooth muscle cellSmooth muscle cellsTCP, Tissue culture polystyreneTGFβ-1, Transforming growth factor beta-1Tissue engineering

Identifiers

PMID36193159
PMCPMC9526190
OpenAlexW4296177688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.