Evidence map›Paper›PMID 36193048›Full record

ArticleiScience2022

Adam10-dependent Notch signaling establishes dental epithelial cell boundaries required for enamel formation.

Thimios A Mitsiadis, Lucia Jimenez-Rojo, Anamaria Balic, Silvio Weber, Paul Saftig, Pierfrancesco Pagella

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. ADAM10 Expression by Ameloblasts Is Essential for Proper Enamel Formation.International journal of molecular sciences · 2024
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Thimios A MitsiadisOrofacial Development and Regeneration, Institute of Oral Biology, Centre for Dental Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland.
Lucia Jimenez-RojoOrofacial Development and Regeneration, Institute of Oral Biology, Centre for Dental Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland.
Anamaria BalicOrofacial Development and Regeneration, Institute of Oral Biology, Centre for Dental Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland.
Silvio WeberMiltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.
Paul SaftigBiochemical Institute, Christian-Albrechts-Universität Kiel, 24118 Kiel, Germany.
Pierfrancesco PagellaOrofacial Development and Regeneration, Institute of Oral Biology, Centre for Dental Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland.
University of Zurich · CHChristian-Albrechts-Universität zu Kiel · DEMiltenyi Biotec (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The disintegrin and metalloproteinase Adam10 is a membrane-bound sheddase that regulates Notch signaling and ensures epidermal integrity. To address the function of Adam10 in the continuously growing incisors, we used Keratin14

Indexed as

Cell biologyDevelopmental biologyModel organism

Identifiers

PMID36193048
PMCPMC9526176
OpenAlexW4296071759

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.