ArticleBMC endocrine disorders2022
The triglyceride glucose index is associated with future cardiovascular disease nonlinearly in middle-aged and elderly Chinese adults.
Article in BMC endocrine disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 15 citations in OpenAlex.
- Association between the triglycerideZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Triglyceride glucose-weight-adjusted waist index (TyG-WWI): the best predictor of diabetes mellitus and mortality risks among TyG and TyG-derived indices.BMC endocrine disorders · 2025Article
- The relationship between triglyceride-glucose index and prospective key clinical outcomes in patients hospitalised for coronary artery disease.Cardiovascular diabetology · 2024Article
- Association of triglyceride-glucose index trajectory and frailty in urban older residents: evidence from the 10-year follow-up in a cohort study.Cardiovascular diabetology · 2023Article
- An innovative model for predicting coronary heart disease using triglyceride-glucose index: a machine learning-based cohort study.Cardiovascular diabetology · 2023Article
- Association of triglyceride-glucose index with the prevalence of cardiovascular disease in malnourished/non-malnourished patients: a large cross-sectional study.Frontiers in cardiovascular medicine · 2023Article
- Relationship between a novel non-insulin-based metabolic score for insulin resistance (METS-IR) and coronary artery calcification.BMC endocrine disorders · 2022Article
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to investigate the association between triglyceride glucose index and cardiovascular disease (CVD) development in the Chinese middle-aged and elderly population using the China Health and Retirement Longitudinal Study dataset 2011-2018.
methodsBasic characteristics of participants, including sociodemographic information, and health conditions, were acquired. Logistic regression analyses and restricted cubic spline regression analyses were conducted to investigate the association between the triglyceride glucose index and future CVD risks. Subgroup analyses were performed to evaluate potential interaction.
resultsSeven hundred fifty-three of 6114 (12.3%) participants have developed CVD in 2018 over an approximately 7-year follow-up. The logistic regression analysis exhibited that compared to the lowest triglyceride glucose index group, the multivariable OR for future CVD was 0.985 (95%CI 0.811-1.198) in the T2 triglyceride glucose index group and 1.288 (95%CI 1.068-1.555) in the T3 TyG index (P for trend 0.006). The restricted cubic spline regression analysis showed the nonlinear association between triglyceride glucose index and CVD incidence; the cut-off values were 8.07 and 8.57, respectively, after total adjustment. Gender, fast blood glucose, and triglycerides interacted with triglyceride glucose index and CVD except for BMI.
conclusionThe triglyceride glucose index was nonlinearly related to the risk of future cardiovascular disease in the middle-aged and elderly Chinese population.
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