ArticleBMC complementary medicine and therapies2022
Topical administration of Juglans regia L. leaf extract accelerates diabetic wound healing.
Article in BMC complementary medicine and therapies, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Wound Healing Activity ofResearch square · 2026Article
- Effect of antioxidants derived from Copaifera langsdorffii Desf. on skin tissue repair in diabetic rats.Revista brasileira de enfermagem · 2026Article
- Rheological Characterization of Lemon Oil-Loaded Eucerin Cream and Aquaphor Ointment.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Unveiling Wound Healing Properties of Biostimulated Walnut Kernel Extracts via Epithelial Mesenchymal Transition: Switching a Nutritional Matrix into a Therapeutic Remedy.Antioxidants (Basel, Switzerland) · 2025Article
- Topical application of phycocyanin accelerates wound healing in STZ-induced diabetic rats via activation of the Nrf2 signaling pathway.3 Biotech · 2025Article
- Foods for Sleep Improvement: A Review of the Potential and Mechanisms Involved.Foods (Basel, Switzerland) · 2025Review
- Advanced Natural Therapeutics and Delivery Strategies for Diabetic Foot Ulcers: A Mini Review.Drug design, development and therapy · 2025Review
- Decellularized Persian walnut leaf (Frontiers in bioengineering and biotechnology · 2025Article
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5 authors.
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Abstract
backgroundDiabetic wounds are one of the most important issues in diabetic patients. It seems that Juglans regia L. leaf with antioxidant and anti-inflammatory potentials can be profitable for healing of diabetic wounds. The aim of present study was to investigate the topical administration of Juglans regia L. leaf extract in diabetic wound healing.
methodsSeventy-five diabetic male rats were randomly divided into 5 groups (n = 15), including: untreated (Control) group, Eucerin group, 2% Juglans regia L. ointment (JRL 2%) group, 5% Juglans regia L. ointment (JRL 5%) group, and Phenytoin group as a reference drug. Sampling was performed at days 7, 14, and 21 after surgery. Evaluation tests included stereology, immunohistochemistry, molecular, and biomechanical.
resultsOur results showed that the wound closure rate, volumes of newly formed of epidermis and dermis, density of fibroblasts and blood vessels, collagen deposition, density of proliferation cells, expression levels of TGF-β and VEGF genes, and biomechanical characteristics were significantly higher in extract groups compared to control and eucerin groups, however, these changes were considerable in the JRL 5% group (P < 0.05). This is while that the density of neutrophils and expression levels of TNF-α and IL-1β genes in the extract groups, especially in the JRL 5% group, were significantly reduced compared to control and eucerin groups (P < 0.05).
conclusionTopical administration of Juglans regia L. leaf extract, especially in 5% concentration, considerably accelerates diabetic wound healing.
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