Evidence map›Paper›PMID 36192596›Full record

ReviewNature reviews. Neuroscience2022

Multiregion neuronal activity: the forest and the trees.

Timothy A Machado, Isaac V Kauvar, Karl Deisseroth

Abstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

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  6. Input-dependent directionality of interactions between cortical areas.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Timothy A Machado *Department of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0003-3762-1460
Isaac V Kauvar *Department of Bioengineering, Stanford University, Stanford, CA, USA.
Karl DeisserothDepartment of Bioengineering, Stanford University, Stanford, CA, USA. deissero@stanford.edu.ORCID 0000-0001-9440-3967

Funding

OPTICAL NEUROMODULATION TECHNOLOGY FOR LONG TIMESCALESR01MH086373 · NIMH · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2010 to 2025
$9.1M
Brainwide Computations Underlying Future Action PlansK99NS116122 · NINDS · STANFORD UNIVERSITY · PI MACHADO, TIMOTHY ALOYSIUS · 2020 to 2021
$246k
Howard Hughes Medical InstituteNIMH NIH HHS R01 MH086373NINDS NIH HHS K99 NS116122
6 · The paper itself

Abstract

The past decade has witnessed remarkable advances in the simultaneous measurement of neuronal activity across many brain regions, enabling fundamentally new explorations of the brain-spanning cellular dynamics that underlie sensation, cognition and action. These recently developed multiregion recording techniques have provided many experimental opportunities, but thoughtful consideration of methodological trade-offs is necessary, especially regarding field of view, temporal acquisition rate and ability to guarantee cellular resolution. When applied in concert with modern optogenetic and computational tools, multiregion recording has already made possible fundamental biological discoveries - in part via the unprecedented ability to perform unbiased neural activity screens for principles of brain function, spanning dozens of brain areas and from local to global scales.

Indexed as

NeuronsOptogeneticsBrainCognitionHumansSensation

Identifiers

PMID36192596
PMCPMC10327445

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.