ArticleCommunications biology2022
Mining the equine gut metagenome: poorly-characterized taxa associated with cardiovascular fitness in endurance athletes.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 23 citations in OpenAlex.
- Gut Microbiota as a Molecular Regulator of Mineral Homeostasis in Horses: Mechanisms and Future Perspectives.International journal of molecular sciences · 2026Review
- From Diet to Disease: The Role of the Gut Microbiome and Microbial Metabolites in Horses.Veterinary sciences · 2026Review
- A Comprehensive Review of the Equine Gut Microbiome in Health and Disease.Veterinary sciences · 2026Review
- Long-Read Sequencing for Species-Level Resolution of the Equine Gut Microbiota Reveals the Need for Improved Databases.Animals : an open access journal from MDPI · 2026Article
- Modulation of the gut-heart axis by exercise in diabetic cardiomyopathy: Microbial mechanisms and clinical implications.iScience · 2026Review
- IME_Rho_tet, a novel family of putative integrative mobilizable elements spreading tetracycline resistance genesMicrobial genomics · 2026Article
- Comparative metagenomic analysis of gut microbiomes in Yunnan ponies and Dutch warmblood horses.Frontiers in microbiology · 2026Article
- A guide to network analysis, multi-omics integration, and applications in livestock microbiome research.World journal of microbiology & biotechnology · 2025Review
- Decoding the dynamics of calves' respiratory and gut microbiota: exploring stability, resistance, and individual patterns.Animal microbiome · 2025Article
- Impact of Low-Starch Dietary Modifications on Faecal Microbiota Composition and Gastric Disease Scores in Performance Horses.Animals : an open access journal from MDPI · 2025Article
- Multiomic analysis of different horse breeds reveals that gut microbial butyrate enhances racehorse athletic performance.NPJ biofilms and microbiomes · 2025Article
- Article
- Effect of Management System on Fecal Microbiota in Arabian Horses: Preliminary Results.Veterinary sciences · 2025Article
- Mechanisms underlying alterations of the gut microbiota by exercise and their role in shaping ecological resilience.FEMS microbiology reviews · 2025Review
- Phylogenetic diversity and community structure ofFrontiers in microbiology · 2025Article
- Exploring the distinctive characteristics of gut microbiota across different horse breeds and ages using metataxonomics.Frontiers in cellular and infection microbiology · 2025Article
- Gut microbiome regulation in equine animals: current understanding and future perspectives.Frontiers in microbiology · 2025Review
- Fibrolytic efficiency of the large intestine microbiota may benefit running speed in French trotters: A pilot study.Physiological reports · 2024Article
- Gut Microbiota Profiling as a Promising Tool to Detect Equine Inflammatory Bowel Disease (IBD).Animals : an open access journal from MDPI · 2024Article
- Early-life gut bacterial community structure predicts disease risk and athletic performance in horses bred for racing.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging evidence indicates that the gut microbiome contributes to endurance exercise performance. Still, the extent of its functional and metabolic potential remains unknown. Using elite endurance horses as a model system for exercise responsiveness, we built an integrated horse gut gene catalog comprising ~25 million unique genes and 372 metagenome-assembled genomes. This catalog represents 4179 genera spanning 95 phyla and functional capacities primed to exploit energy from dietary, microbial, and host resources. The holo-omics approach shows that gut microbiomes enriched in Lachnospiraceae taxa are negatively associated with cardiovascular capacity. Conversely, more complex and functionally diverse microbiomes are associated with higher glucose concentrations and reduced accumulation of long-chain acylcarnitines and non-esterified fatty acids in plasma, suggesting increased ß-oxidation capacity in the mitochondria. In line with this hypothesis, more fit athletes show upregulation of mitochondrial-related genes involved in energy metabolism, biogenesis, and Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.