Evidence map›Paper›PMID 36192448›Full record

ArticleArchives of microbiology2022

LC-MS/MS and GC-MS based phytochemical perspectives and antimicrobial effects of endophytic fungus Chaetomium ovatoascomatis isolated from Euphorbia milii.

Kamel H Shaker, Moustafa M Zohair, Amal Z Hassan, Heba-Tollah M Sweelam, Warda E Ashour

Open access · hybridAbstract read
In one paragraph

Article in Archives of microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  8. Effective Use ofCurrent issues in molecular biology · 2024
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  13. Two Novel Plant-Growth-PromotingPlants (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Kamel H ShakerChemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Institute, National Research Center, El-Behoos st, Dokki, Giza, 12622, Egypt. kamelshaker11@yahoo.com.ORCID http://orcid.org/0000-0001-9876-1251
Moustafa M ZohairChemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Institute, National Research Center, El-Behoos st, Dokki, Giza, 12622, Egypt.ORCID http://orcid.org/0000-0002-3662-8452
Amal Z HassanChemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Institute, National Research Center, El-Behoos st, Dokki, Giza, 12622, Egypt.ORCID http://orcid.org/0000-0002-5574-8791
Heba-Tollah M SweelamChemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Institute, National Research Center, El-Behoos st, Dokki, Giza, 12622, Egypt.ORCID http://orcid.org/0000-0001-6876-9009
Warda E AshourChemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Institute, National Research Center, El-Behoos st, Dokki, Giza, 12622, Egypt.ORCID http://orcid.org/0000-0002-1182-0560
National Research Centre · EGKyushu University · JP

Funding

National Research Centre E-120207
6 · The paper itself

Abstract

The antimicrobial activity of endophytic fungi isolated from Euphorbia milii was evaluated against Gram-positive, Gram-negative bacteria, unicellular yeast, and filamentous fungi. Chaetomium ovatoascomatis NRC was identified morphologically and genetically as the most active strain. The total ethyl acetate extract of C. ovatoascomatis NRC demonstrated significant antimicrobial activity against Gram-negative; Escherichia coli, Salmonella enteric, and fungi; Aspergillus niger with MIC of 62.5 ug/ml. Whereas n-hexane fraction demonstrated broader activity against Gram-positive; Bacillus subtilis, Lactobacillus cereus, Gram-negative; Escherichia coli and Salmonella enteric, fungi; Candida albicans and F. solani. LC-MS/MS analysis of ethyl acetate strain extract and GC-MS analysis of the n-hexane fraction were used to identify the metabolites of the strain extract. LC-MS/MS determined three major metabolites with potential antimicrobial activities including grevilline B, aflatoxin G2 and apigenin. GC-MS analysis of n-hexane fraction tentatively identified 30 compounds, where 9,12-octadecadienoic acid methyl ester was the major compound.

Indexed as

Anti-Infective AgentsChaetomiumEuphorbiaAcetatesApigeninBacillus subtilisChromatography, LiquidEndophytesEscherichia coliEstersGas Chromatography-Mass SpectrometryGram-Negative BacteriaHexanesLinoleic AcidMicrobial Sensitivity TestsPhytochemicalsAcetatesAnti-Infective AgentsApigeninEstersethyl acetateHexanesLinoleic Acidn-hexanePhytochemicalsAntimicrobialChaetomium sp. metabolitesEuphorbia miliiFungal endophytesGC–MSLC–MS/MS

Identifiers

PMID36192448
PMCPMC9529702
OpenAlexW4300772164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.