ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
The Age of Reason: Functional Brain Network Development during Childhood.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 67 citations in OpenAlex.
- Randomized clinical trial on the effects of early cognitive interventions for children with acquired brain injury.Scientific reports · 2025Trial
- Individualized Network Topography in Pre-adolescent Children and Adults Using Naturalistic Precision fMRI.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Baseline electrophysiology versus oxidative metabolism as traits of inter-network differences in neurometabolic association.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Linking temporal dynamics of children's natural behavior to brain development.Developmental cognitive neuroscience · 2026Article
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The developmental trajectory of the social brain: A movie-based exploration from childhood to adolescence.Developmental cognitive neuroscience · 2026Article
- The unity and diversity of functional brain connectivity underlying executive function tasks.Developmental cognitive neuroscience · 2026Article
- Developing a multi-modal neuroimaging-based BrainAge model across childhood.bioRxiv : the preprint server for biology · 2026Article
- Article
- Children and adults use distinct neurocognitive mechanisms to support successful memory-based inference.bioRxiv : the preprint server for biology · 2026Article
- Task-evoked functional connectivity exhibits novel and strengthened relationships with executive function relative to the resting state.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Predictive associations between brain functional connectivity, motor abilities, and executive function development in early childhood: a longitudinal machine learning study.Journal of neuroengineering and rehabilitation · 2026Article
- The Cognitive-Affective Social Processing and Emotion Regulation (CASPER) model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Salience network segregation and symptom profiles in psychosis risk subgroups among youth and early adults.Schizophrenia (Heidelberg, Germany) · 2025Article
- Full interhemispheric integration sustained by a fraction of posterior callosal fibers.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Development of Neural Inhibition across Species: Insights from the Hurst Exponent.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Sources of outdoor air pollution exposure and child brain network development across the United States.bioRxiv : the preprint server for biology · 2025Article
- A hierarchical model of early brain functional network development.Trends in cognitive sciences · 2025Review
- Precision functional mapping reveals less inter-individual variability in the child vs. adult human brain.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Human childhood is characterized by dramatic changes in the mind and brain. However, little is known about the large-scale intrinsic cortical network changes that occur during childhood because of methodological challenges in scanning young children. Here, we overcome this barrier by using sophisticated acquisition and analysis tools to investigate functional network development in children between the ages of 4 and 10 years ([Formula: see text]; 50 female, 42 male). At multiple spatial scales, age is positively associated with brain network segregation. At the system level, age was associated with segregation of systems involved in attention from those involved in abstract cognition, and with integration among attentional and perceptual systems. Associations between age and functional connectivity are most pronounced in visual and medial prefrontal cortex, the two ends of a gradient from perceptual, externally oriented cortex to abstract, internally oriented cortex. These findings suggest that both ends of the sensory-association gradient may develop early, in contrast to the classical theories that cortical maturation proceeds from back to front, with sensory areas developing first and association areas developing last. More mature patterns of brain network architecture, controlling for age, were associated with better visuospatial reasoning abilities. Our results suggest that as cortical architecture becomes more specialized, children become more able to reason about the world and their place in it.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.