Evidence map›Paper›PMID 36192094›Full record

ArticleBMJ open2022

COVID-19 during pregnancy and risk of pregnancy loss (miscarriage or stillbirth): a systematic review protocol.

Jennifer Campbell, Rachael Williams, Mia Harley, Krishnan Bhaskaran

Abstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jennifer CampbellNCDE, London School of Hygiene & Tropical Medicine Faculty of Epidemiology and Population Health, London, UK jennifer.campbell@mhra.gov.uk.ORCID 0000-0002-0684-4437
Rachael WilliamsClinical Practice Research Datalink, Medicines and Healthcare Products Regulatory Agency, London, UK.
Mia HarleyNCDE, London School of Hygiene & Tropical Medicine Faculty of Epidemiology and Population Health, London, UK.
Krishnan BhaskaranNCDE, London School of Hygiene & Tropical Medicine Faculty of Epidemiology and Population Health, London, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

introductionThe COVID-19 pandemic has led to concerns about potential adverse pregnancy outcomes associated with infection, resulting in intensive research. Numerous studies have attempted to examine whether COVID-19 is associated with an increased risk of pregnancy loss. However, studies and reviews to date have drawn differing conclusions. The aim of this systematic review is to provide a summary of all quantitative research on the relationship between pregnancy loss and COVID-19 infection and, if appropriate, to synthesise the evidence into an overall effect estimate. METHODS AND ANALYSIS: Three publication databases (Embase, PubMed and Cochrane) and four preprint databases (medRxiv, Lancet Preprint, Gates Open Research and Wellcome Open Research) will be searched. Boolean logic will be used to combine terms associated with pregnancy loss and COVID-19. The population of interest are pregnant women. Retrieved results will be assessed in two phases: (1) abstract screening and (2) full text evaluation. All studies which compare pregnancy loss outcomes in women who had COVID-19 versus those who did not quantitatively will be included. Narrative and non-English studies will be excluded. Two reviewers will screen independently, with results compared and discrepancies resolved by the study team. Study quality and risk of bias will be assessed using a quality appraisal tool. Results will be summarised descriptively and where possible synthesised in a meta-analysis. ETHICS AND DISSEMINATION: This systematic review requires no ethical approval. This review will be published in a peer-reviewed journal and provide an important update in a rapidly evolving field of research. PROSPERO REGISTRATION NUMBER: CRD42022327437.

Indexed as

Abortion, SpontaneousCOVID-19FemaleHumansMeta-Analysis as TopicPandemicsPregnancyPregnancy OutcomeResearch DesignStillbirthSystematic Reviews as TopicCOVID-19EPIDEMIOLOGYOBSTETRICS

Identifiers

PMID36192094
PMCPMC9534774

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.