Evidence map›Paper›PMID 36192034›Full record

ArticleLife science alliance2022

Translatome profiling in fatal familial insomnia implicates TOR signaling in somatostatin neurons.

Susanne Bauer, Lars Dittrich, Lech Kaczmarczyk, Melvin Schleif, Rui Benfeitas, Walker S Jackson

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Susanne BauerDepartment of Biomedical and Clinical Sciences, Wallenberg Center for Molecular Medicine, Linköping University, Linköping, Sweden.ORCID 0000-0003-4731-5002
Lars DittrichGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Lech KaczmarczykDepartment of Biomedical and Clinical Sciences, Wallenberg Center for Molecular Medicine, Linköping University, Linköping, Sweden.ORCID 0000-0003-2747-3134
Melvin SchleifGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Rui BenfeitasDepartment of Biochemistry and Biophysics, National Bioinformatics Infrastructure Sweden (NBIS), Science for Life Laboratory, Stockholm University, Stockholm, Sweden.
Walker S JacksonDepartment of Biomedical and Clinical Sciences, Wallenberg Center for Molecular Medicine, Linköping University, Linköping, Sweden walker.jackson@liu.se.ORCID 0000-0002-3003-5509
Linköping University · SEGerman Center for Neurodegenerative Diseases · DEStockholm University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selective neuronal vulnerability is common in neurodegenerative diseases but poorly understood. In genetic prion diseases, including fatal familial insomnia (FFI) and Creutzfeldt-Jakob disease (CJD), different mutations in the

Indexed as

Creutzfeldt-Jakob SyndromeInsomnia, Fatal FamilialMonomeric GTP-Binding ProteinsNeurodegenerative DiseasesPrion DiseasesAnimalsMiceNeuronsSomatostatinTOR Serine-Threonine KinasesMonomeric GTP-Binding ProteinsSomatostatinTOR Serine-Threonine Kinases

Identifiers

PMID36192034
PMCPMC9531780
OpenAlexW4300863410

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.