Evidence map›Paper›PMID 36191885›Full record

ArticleExperimental hematology2023

Preclinical studies on the use of a P-selectin-blocking monoclonal antibody to halt progression of myelofibrosis in the Gata1

Paola Verachi, Francesca Gobbo, Fabrizio Martelli, Mario Falchi, Antonio di Virgilio, Giuseppe Sarli, Celine Wilke, Andreas Bruederle, Anirudh Prahallad, Francesca Arciprete and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental hematology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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  4. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Paola VerachiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Italy.
Francesca GobboDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Italy; Department of Veterinary Medical Sciences, University of Bologna, Italy.
Fabrizio MartelliNational Center for Preclinical and Clinical Research and Evaluation of Pharmaceutical Drugs, Istituto Superiore di Sanità, Rome, Italy.
Mario FalchiNational Center for HIV/AIDS Research, Istituto Superiore di Sanità, Rome, Italy.
Antonio di VirgilioCenter for Animal Experimentation and Well-being, Istituto Superiore di Santà, Rome, Italy.
Giuseppe SarliDepartment of Veterinary Medical Sciences, University of Bologna, Italy.
Celine WilkeNovartis (United States), East Hanover, NJ, USA.
Andreas BruederleNovartis (United States), East Hanover, NJ, USA.
Anirudh PrahalladNovartis (United States), East Hanover, NJ, USA.
Francesca ArcipreteUnit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy.
Maria ZingarielloUnit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy.
Anna Rita MigliaccioUnit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy; Altius Institute for Biomedical Sciences, Seattle, WA, USA. Electronic address: amigliaccio@altius.org.
Istituto Superiore di Sanità · ITNovartis (United States) · USUniversità Campus Bio-Medico · ITUniversity of Bologna · IT

Funding

Tissue BankP01CA108671 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Ronald Hoffman · 2006 to 2026
$82.0M
Generation of cultured RBCs with rare phenotypes for transfusion from sources usually discarded during regular blood donationsR01HL134684 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BIEKER, JAMES J, MIGLIACCIO, ANNA RITA F · 2018 to 2021
$1.7M
NCI NIH HHS P01 CA108671NHLBI NIH HHS R01 HL134684
6 · The paper itself

Abstract

The bone marrow (BM) and spleen from patients with myelofibrosis (MF), as well as those from the Gata1

Indexed as

Primary MyelofibrosisAnimalsAntibodies, MonoclonalFibrosisMiceNitrilesP-SelectinPyrazolesPyrimidinesTransforming Growth Factor betaAntibodies, MonoclonalNitrilesP-SelectinPyrazolesPyrimidinesruxolitinibTransforming Growth Factor beta

Identifiers

PMID36191885
PMCPMC10450205
OpenAlexW4298627143

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.