ArticleNeuroImage2022
Locus coeruleus catecholamines link neuroticism and vulnerability to tau pathology in aging.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Tracking the Continuous Time Dynamics of Tau and Depressive Symptoms across the Alzheimer's Disease Continuum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Multiscale network reorganization during the multidimensional recollection of naturalistic events.Brain structure & function · 2026Article
- Attenuated pupillary response during visual search in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The monoaminergic systems as drivers of Alzheimer's disease pathophysiology and symptomatology.Current opinion in neurology · 2026Review
- Alzheimer's Disease Pathologies Affect Dopaminergic Neural Mechanisms of Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Defining the contributions of tau pathology in the amygdala to increasing depressive symptoms in aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Locus coeruleus MRI contrast, cerebral perfusion, and plasma Alzheimer's disease biomarkers in older adults.Neurobiology of aging · 2025Article
- Different association patterns of emotion regulation and heart rate variability in older and younger adults.Brain communications · 2025Article
- Elevated locus coeruleus metabolism provides resilience against cognitive decline in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Pathological and neurochemical correlates of locus coeruleus functional network activity.Biological psychology · 2024Article
- Poorer aging trajectories are associated with elevated serotonin synthesis capacity.Molecular psychiatry · 2023Article
- Interactive effects of locus coeruleus structure and catecholamine synthesis capacity on cognitive function.Frontiers in aging neuroscience · 2023Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Higher neuroticism is a risk factor for Alzheimer's disease (AD), and is implicated in disordered stress responses. The locus coeruleus (LC)-catecholamine system is activated during perceived threat and is a centerpiece of developing models of the pathophysiology of AD, as it is the first brain region to develop abnormal tau. We examined relationships among the "Big 5" personality traits, LC catecholamine synthesis capacity measured with [
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.