ArticleThe Journal of investigative dermatology2023
Senescent Cells Accumulate in Systemic Sclerosis Skin.
Abstract readLetter
In one paragraph
Article in The Journal of investigative dermatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gene expression meta-analysis reveals aging and cellular senescence signatures in scleroderma-associated interstitial lung disease.Frontiers in immunology · 2024Pooled it
- Immune-stromal dysregulation and senescence in chronic spontaneous urticaria.The journal of allergy and clinical immunology. Global · 2026Article
- A potent inhibitor of PAI-1, MDI-2517, mitigates disease severity in a preclinical systemic sclerosis model.JCI insight · 2026Article
- Telomere Length of Peripheral Blood Leukocytes Predicts Disease Severity and Worse Survival in Systemic Sclerosis.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Regulating the regulators via targeting CD38 in the tumor microenvironment.Frontiers in immunology · 2026Review
- Dermatomyositis is characterized by JAK1-mediated monocyte-driven vasculopathy and inflammation.Science translational medicine · 2025Article
- Decoding vascular dysfunction in systemic sclerosis: from endothelial damage to clinical implications.Current opinion in rheumatology · 2025Review
- Tissue Fibrosis Decoded via Cellular Senescence: Mechanisms, Treatments, and Emerging Technologies.Aging and disease · 2025Review
- Emerging Techniques in Spatial Multiomics: Fundamental Principles and Applications to Dermatology.The Journal of investigative dermatology · 2025Review
- An international perspective on the future of systemic sclerosis research.Nature reviews. Rheumatology · 2025Review
- Promoting ER stress in a plasmacytoid dendritic cell line drives fibroblast activation.Cell communication and signaling : CCS · 2025Article
- Senescence in diffuse systemic sclerosis is elevated and may play a role in fibrosis.Clinical and experimental immunology · 2025Article
- Targeting CD13/Aminopeptidase N as a Novel Therapeutic Approach for Scleroderma Fibrosis.Arthritis & rheumatology (Hoboken, N.J.) · 2025Article
- Connecting the Dots: Telomere Shortening and Rheumatic Diseases.Biomolecules · 2024Review
- Redox Pathogenesis in Rheumatic Diseases.ACR open rheumatology · 2024Review
- Aging, senescence, and cutaneous wound healing-a complex relationship.Frontiers in immunology · 2024Review
- The potential for senotherapy as a novel approach to extend life quality in veterinary medicine.Frontiers in veterinary science · 2024Review
- Heavy-chain antibody targeting of CD38 NADScientific reports · 2023Article
- Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study.International journal of molecular sciences · 2023Article
- The role of immunosuppressive myofibroblasts in the aging process and age-related diseases.Journal of molecular medicine (Berlin, Germany) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Bo ShiDepartment of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Ilinois, USA.
Pei-Suen TsouDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA; Michigan Scleroderma Program, University of Michigan, Ann Arbor, Michigan, USA.
Feiyang MaDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Michael P MarianiDepartment of Biomedical Data Science, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA.
Megan N MattichakDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Nathan K LeBrasseurRobert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, Mayo Clinic Rochester, Minnesota, USA.
Eduardo N ChiniSignal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, Florida, USA.
Robert LafyatisDivision of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Dinesh KhannaDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA; Michigan Scleroderma Program, University of Michigan, Ann Arbor, Michigan, USA.
Michael L WhitfieldDepartment of Biomedical Data Science, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire, USA.
Johann E GudjonssonDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
John VargaDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA; Michigan Scleroderma Program, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: vargaj@umich.edu.
Funding
Systems Biology CoreP50AR080612 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROBERT A. LAFYATIS · 2022 to 2026
$9.5MUniversity of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson · 2019 to 2026
$6.6MThe Sir2-p53-IGF Link in Mammalian Life-Span ControlR01AG026094 · NIA · UNIVERSITY OF VIRGINIA · PI CHINI, EDUARDO N · 2006 to 2016
$3.8MTherapeutic implication of CD38 in CLLR01CA233790 · NCI · MAYO CLINIC JACKSONVILLE · PI CHINI, EDUARDO N · 2019 to 2023
$3.0MRole of CD38 in NAD metabolism: from the basic biology of aging to translationR01AG058812 · NIA · MAYO CLINIC ROCHESTER · PI CHINI, EDUARDO N · 2018 to 2022
$2.0MSirtuins: novel determinants and therapeutic target in systemic sclerosisR56AG054207 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI VARGA, JOHN · 2016 to 2016
$520kTargeting NAD metabolism to treat systemic sclerosisR21AR074523 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHINI, EDUARDO N, VARGA, JOHN · 2018 to 2019
$396kNCI NIH HHS R01 CA233790NIAMS NIH HHS P30 AR075043NIAMS NIH HHS P50 AR080612NIAMS NIH HHS R21 AR074523NIA NIH HHS R01 AG026094NIA NIH HHS R01 AG058812NIA NIH HHS R56 AG054207
Abstract
PubMed holds no abstract for this paper.
Indexed as
Scleroderma, SystemicSkin DiseasesCellular SenescenceHumansSkin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.