ArticleChest2023
Patient and Nodule Characteristics Associated With a Lung Cancer Diagnosis Among Individuals With Incidentally Detected Lung Nodules.
Article in Chest, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 17 citations in OpenAlex.
- Grayscale ultrasound radiomics for characterizing subpleural pulmonary lesions: a multicenter prospective study.Insights into imaging · 2026Article
- Perceptions of artificial intelligence among pulmonologists.ERJ open research · 2026Article
- Clinicopathological characteristics associated with intrapulmonary metastasis rather than single primary lung cancer at first diagnosis: a study based on the Surveillance, Epidemiology, and End Results database using Bayesian networks and structural equation modeling.Translational lung cancer research · 2026Article
- Cost-effectiveness analysis of artificial intelligence-assisted risk stratification of indeterminate pulmonary nodules.PloS one · 2026Article
- Large-Scale T-cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules.Cancer research · 2025Article
- Pulmonary nodules in Denmark: occurrence, resource use, and risk of lung cancer and death.Acta oncologica (Stockholm, Sweden) · 2025Article
- Longitudinal variability of CT imaging features for predicting pulmonary nodule invasiveness: A multicenter study.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
- Computer-aided Nodule Detection in the Lung Apices in Head and Neck Computed Tomography Angiography: An Unexpected Opportunity.Journal of thoracic imaging · 2025Article
- OM-85, a Bacterial Lysate, Reduces Pulmonary Nodule Malignant Probability: A Retrospective Study.The clinical respiratory journal · 2025Article
- ACPA is a main risk factor for CT-proven pulmonary nodule progression in patients with rheumatoid arthritis.Clinical rheumatology · 2025Article
- Advances in modelling the risk of benign and malignant lung nodules.Frontiers in oncology · 2025Review
- [Research Progress of Comprehensive Follow-up Management Strategy on the Natural History of Simultaneous, Persistent Multiple Pulmonary Ground-glass Nodules].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024Review
- Artificial intelligence-driven computer aided diagnosis system provides similar diagnosis value compared with doctors' evaluation in lung cancer screening.BMC medical imaging · 2024Article
- Plasma nicotine and its metabolite as biomarkers of tobacco exposure and their relevance to pulmonary nodule.Biomarkers in medicine · 2024Article
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- Assessing a biomarker's ability to reduce invasive procedures in patients with benign lung nodules: Results from the ORACLE study.PloS one · 2023Observational
- A lung cancer risk prediction model for nonsmokers: A retrospective analysis of lung nodule cohorts in China.Journal of clinical laboratory analysis · 2022Article
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundPulmonary nodules are a common incidental finding on CT imaging. Few studies have described patient and nodule characteristics associated with a lung cancer diagnosis using a population-based cohort. RESEARCH QUESTION: Does a relationship exist between patient and nodule characteristics and lung cancer among individuals with incidentally detected pulmonary nodules, and can this information be used to create exploratory lung cancer prediction models with reasonable performance characteristics? STUDY DESIGN AND
methodsWe conducted a retrospective cohort study of adults older than 18 years with lung nodules of any size incidentally detected by chest CT imaging between 2005 and 2015. All patients had at least 2 years of complete follow-up. To evaluate the relationship between patient and nodule characteristics and lung cancer, we used binomial regression. We used logistic regression to create prediction models, and we internally validated model performance using bootstrap optimism correction.
resultsAmong 7,240 patients with a median age of 67 years, 56% of whom were women, with a median BMI of 28 kg/m
interpretationLung cancer is uncommon among individuals with incidentally detected lung nodules. Some, but not all, previously identified factors associated with lung cancer also were associated with this outcome in this sample. These findings may have implications for clinical practice, future practice guidelines, and the development of novel lung cancer prediction models for individuals with incidentally detected lung nodules.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.