Trial reportFacial plastic surgery : FPS2023
Efficacy and Safety of Polycaprolactone in Treating Nasolabial Folds: A Prospective, Multicenter, and Randomized Controlled Trial.
Trial report in Facial plastic surgery : FPS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Safety and Potential Complications of Facial Wrinkle Correction with Dermal Fillers: A Systematic Literature Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Three-stage V-line Technique with Polycaprolactone Filler for Facial Contour Restoration.Plastic and reconstructive surgery. Global open · 2026Article
- Review
- A Preliminary Study of Polycaprolactone Filler After Hyaluronidase for Facial Overfilled Syndrome.Clinical, cosmetic and investigational dermatology · 2026Article
- Efficacy and Safety of Polycaprolactone Filler in Nonsurgical Rhinoplasty: A Pilot Study.Clinical, cosmetic and investigational dermatology · 2026Article
- Pilot Study: Efficacy and Safety of Polycaprolactone Collagen Stimulator for Middle Third of the Face.Plastic and reconstructive surgery. Global open · 2025Article
- Comparing the Safety and Effectiveness of PCL and PLLA Injections for Nasolabial Fold Correction.Journal of cosmetic dermatology · 2025Article
- Morphometric effectiveness of calcium hydroxylapatite application in zygomatic and malar area on correction of nasolabial folds.Medicine · 2025Observational
- Skin Wound Healing Following Injecting Hyaluronic Acid Rejuvenating Complex, Polycaprolactone, or Combination Therapy: An Experimental Study.Journal of cosmetic dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nasolabial folds (NLFs) are the most pronounced sign of facial aging. This study explored the efficacy and safety of polycaprolactone gel in treating Chinese patients with moderate-to-severe NLFs. Patients with moderate-to-severe NLF who wished to be treated by dermal fillers were recruited from three centers between July 2017 and September 2019. The randomizing ratio was 1:1 in the polycaprolactone group (polycaprolactone injection) or control group (sodium hyaluronate gel injection). The primary endpoint was the effectiveness rate of Wrinkle Severity Rating Score (WSRS) scores at 12 months after injection. The full-analysis set (FAS) and safety sets had 80 patients in the polycaprolactone group and control group, respectively. In the FAS, the effectiveness rate at 12 months in the polycaprolactone group was 88.8% compared with 23.8% in controls (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.