Evidence map›Paper›PMID 36191434›Full record

ArticleJournal of biomechanics2022

Personalization improves the biomechanical efficacy of foot progression angle modifications in individuals with medial knee osteoarthritis.

Scott D Uhlrich, Julie A Kolesar, Łukasz Kidziński, Melissa A Boswell, Amy Silder, Garry E Gold, Scott L Delp, Gary S Beaupre

Abstract read
In one paragraph

Article in Journal of biomechanics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Effects of Subject-Specific Robot-Guided Off-Axis Stepping Training in Individuals With Medial Knee Osteoarthritis.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
    Article
  8. Retraining Gastrocnemius Muscle Coordination Reduces Late-Stance Knee Contact Force in Individuals With Knee Osteoarthritis.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
    Article
  9. Review
  10. Article
  11. Marker Data Enhancement for Markerless Motion Capture.IEEE transactions on bio-medical engineering · 2025
    Article
  12. Article
  13. Article
  14. Marker Data Enhancement For Markerless Motion Capture.bioRxiv : the preprint server for biology · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Knee adduction moment decomposition: Toward better clinical decision-making.Frontiers in bioengineering and biotechnology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Scott D UhlrichDepartment of Mechanical Engineering, Stanford University, Stanford, CA 94305, United States; Department of Bioengineering, Stanford University, Stanford, CA 94305, United States; Musculoskeletal Research Laboratory, VA Palo Alto Healthcare System, Palo Alto, CA 94304, United States. Electronic address: suhlrich@stanford.edu.
Julie A KolesarDepartment of Bioengineering, Stanford University, Stanford, CA 94305, United States; Musculoskeletal Research Laboratory, VA Palo Alto Healthcare System, Palo Alto, CA 94304, United States.
Łukasz KidzińskiDepartment of Bioengineering, Stanford University, Stanford, CA 94305, United States.
Melissa A BoswellDepartment of Bioengineering, Stanford University, Stanford, CA 94305, United States.
Amy SilderDepartment of Bioengineering, Stanford University, Stanford, CA 94305, United States; Musculoskeletal Research Laboratory, VA Palo Alto Healthcare System, Palo Alto, CA 94304, United States.
Garry E GoldDepartment of Radiology, Stanford University, Stanford, CA 94305, United States.
Scott L DelpDepartment of Mechanical Engineering, Stanford University, Stanford, CA 94305, United States; Department of Bioengineering, Stanford University, Stanford, CA 94305, United States; Department of Orthopaedic Surgery, Stanford University, Stanford, CA 94305, United States.
Gary S BeaupreDepartment of Bioengineering, Stanford University, Stanford, CA 94305, United States; Musculoskeletal Research Laboratory, VA Palo Alto Healthcare System, Palo Alto, CA 94304, United States.

Funding

Rapid MRI for Evaluation of OsteoarthritisR01EB002524 · NIBIB · STANFORD UNIVERSITY · PI Akshay Chaudhari, Garry E Gold · 2003 to 2026
$10.1M
TR&D Project 3: OpenSim for PredictionP41EB027060 · NIBIB · STANFORD UNIVERSITY · PI SCOTT L DELP · 2020 to 2026
$9.7M
Advanced MR Imaging of Early OsteoarthritisK24AR062068 · NIAMS · STANFORD UNIVERSITY · PI GOLD, GARRY E · 2012 to 2022
$1.7M
NIAMS NIH HHS K24 AR062068NIBIB NIH HHS P41 EB027060NIBIB NIH HHS R01 EB002524RRD VA I01 RX001811
6 · The paper itself

Abstract

Modifying the foot progression angle during walking can reduce the knee adduction moment, a surrogate measure of medial knee loading. However, not all individuals reduce their knee adduction moment with the same modification. This study evaluates whether a personalized approach to prescribing foot progression angle modifications increases the proportion of individuals with medial knee osteoarthritis who reduce their knee adduction moment, compared to a non-personalized approach. Individuals with medial knee osteoarthritis (N=107) walked with biofeedback instructing them to toe-in and toe-out by 5° and 10° relative to their self-selected angle. We selected individuals' personalized foot progression angle as the modification that maximally reduced their larger knee adduction moment peak. Additionally, we used lasso regression to identify which secondary kinematic changes made a 10° toe-in gait modification more effective at reducing the first knee adduction moment peak. Seventy percent of individuals reduced their larger knee adduction moment peak by at least 5% with a personalized foot progression angle modification, which was more than (p≤0.002) the 23-57% of individuals who reduced it with a uniformly assigned 5° or 10° toe-in or toe-out modification. When toeing-in, greater reductions in the first knee adduction moment peak were related to an increased frontal-plane tibia angle (knee more medial than ankle), a more valgus knee abduction angle, reduced contralateral pelvic drop, and a more medialized center of pressure in the foot reference frame. In summary, personalization increases the proportion of individuals with medial knee osteoarthritis who may benefit from a foot progression angle modification.

Indexed as

Osteoarthritis, KneeBiomechanical PhenomenaFootGaitHumansKnee JointBiofeedbackGait retrainingKnee adduction momentOsteoarthritisPrecision medicine

Identifiers

PMID36191434
PMCPMC9889103

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.