Evidence map›Paper›PMID 36191236›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Interkingdom assemblages in human saliva display group-level surface mobility and disease-promoting emergent functions.

Zhi Ren, Hannah Jeckel, Aurea Simon-Soro, Zhenting Xiang, Yuan Liu, Indira M Cavalcanti, Jin Xiao, Nyi-Nyi Tin, Anderson Hara, Knut Drescher and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 56 citations in OpenAlex.

  1. Review
  2. Review
  3. TheApplied and environmental microbiology · 2026
    Article
  4. Article
  5. Article
  6. AJournal of bacteriology · 2026
    Review
  7. Capsaicin inhibits cariogenicJournal of oral microbiology · 2026
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Microorganisms · 2025
    Review
  16. Article
  17. Co-zorbs: Motile, multispecies biofilms aid transport of diverse bacterial species.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Deletion ofFrontiers in cellular and infection microbiology · 2025
    Article
  19. Frontiers in microbiology · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 5 countries.

Zhi RenBiofilm Research Laboratories, Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-3553-1958
Hannah JeckelDepartment of Physics, Philipps-Universität Marburg, 35032 Marburg, Germany.ORCID 0000-0002-7080-4907
Aurea Simon-SoroBiofilm Research Laboratories, Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0003-3656-6834
Zhenting XiangBiofilm Research Laboratories, Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-4823-002X
Yuan LiuBiofilm Research Laboratories, Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Indira M CavalcantiBiofilm Research Laboratories, Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-5296-9812
Jin XiaoEastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY 14620.
Nyi-Nyi TinOral Health Research Institute, Department of Cariology, Operative Dentistry, and Dental Public Health, School of Dentistry, Indiana University, Indianapolis, IN 46202.ORCID 0000-0002-0053-4614
Anderson HaraOral Health Research Institute, Department of Cariology, Operative Dentistry, and Dental Public Health, School of Dentistry, Indiana University, Indianapolis, IN 46202.ORCID 0000-0001-9822-6064
Knut DrescherBiozentrum, University of Basel, 4056 Basel, Switzerland.ORCID 0000-0002-7340-2444
Hyun KooBiofilm Research Laboratories, Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0001-9143-2076
University of Hawaiʻi at Mānoa · USUniversity of Pennsylvania · USCenter for Innovation · US

Funding

S. mutans-C. albicans interactions synergize the virulence of cariogenic biofilmsR01DE025220 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KOO, HYUN · 2015 to 2019
$2.0M
Association between Oral Candida albicans and the Onset of Severe Early Childhood CariesK23DE027412 · NIDCR · UNIVERSITY OF ROCHESTER · PI XIAO, JIN · 2018 to 2022
$748k
Advanced Training at the Interface of Engineering and Oral-Craniofacial SciencesR90DE031532 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KOO, HYUN, STEBE, KATHLEEN J · 2021 to 2025
$505k
NIDCR NIH HHS K23 DE027412NIDCR NIH HHS R01 DE025220NIDCR NIH HHS R90 DE031532
6 · The paper itself

Abstract

Fungi and bacteria often engage in complex interactions, such as the formation of multicellular biofilms within the human body. Knowledge about how interkingdom biofilms initiate and coalesce into higher-level communities and which functions the different species carry out during biofilm formation remain limited. We found native-state assemblages of

Indexed as

BiofilmsSalivaStreptococcus mutansCandida albicansChildDiseaseHumansHyphaePopulation Dynamicsinterkingdom interactionmicrobial mobilityoral biofilmspatial structuresupraorganism

Identifiers

PMID36191236
PMCPMC9565521
OpenAlexW4300594461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.