ArticleCerebral cortex (New York, N.Y. : 1991)2023
Age-related reorganization of functional network architecture in semantic cognition.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Functional connectivity correlates of sequence memory decline in healthy older adults.GeroScience · 2026Article
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- Are Creative People More Susceptible to False Memory? Evidence for Age- and Task-Related Differences.Creativity research journal · 2026Article
- Age related alteration in EEG evoked responses to balance perturbations on an inclined surface.Scientific reports · 2026Article
- Neural Coding of Multiple Linguistic Components During Reading Comprehension Across Development.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Semantic control across Alzheimer's disease phenotypes: cognitive mechanisms and neural correlates.Frontiers in aging neuroscience · 2026Article
- Salience network segregation and symptom profiles in psychosis risk subgroups among youth and early adults.Schizophrenia (Heidelberg, Germany) · 2025Article
- Causal contributions of left inferior and medial frontal cortex to semantic and executive control.Communications biology · 2025Article
- Age-related alterations in alpha and beta oscillations support preservation of semantic processing in healthy aging.npj aging · 2025Article
- Intrinsic functional brain connectivity in adolescent anxiety: Associations with behavioral phenotypes and cross-syndrome network features.Journal of affective disorders · 2025Article
- After cochlear implantation in older adults, enhanced working memory does not fully mediate the relationship between CI and improved semantic fluency.Frontiers in aging neuroscience · 2025Article
- Semantic processing in older adults is associated with distributed neural activation which varies by association and abstractness of words.GeroScience · 2024Article
- Modeling the neurocognitive dynamics of language across the lifespan.Human brain mapping · 2024Article
- Aging effects on dual-route speech processing networks during speech perception in noise.Human brain mapping · 2024Article
- Bayesian modelling disentangles language versus executive control disruption in stroke.Brain communications · 2024Article
- Differences in electroencephalography oscillations between normal aging and mild cognitive impairment during semantic memory retrieval.The European journal of neuroscience · 2023Article
- Task difficulty modulates age-related differences in functional connectivity during word production.Brain and language · 2023Article
- Differential effects of ageing on the neural processing of speech and singing production.Frontiers in aging neuroscience · 2023Article
- TMS over the pre-SMA enhances semantic cognition via remote network effects on task-based activity and connectivity.Brain stimulationArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive aging is associated with widespread neural reorganization processes in the human brain. However, the behavioral impact of such reorganization is not well understood. The current neuroimaging study investigated age differences in the functional network architecture during semantic word retrieval in young and older adults. Combining task-based functional connectivity, graph theory and cognitive measures of fluid and crystallized intelligence, our findings show age-accompanied large-scale network reorganization even when older adults have intact word retrieval abilities. In particular, functional networks of older adults were characterized by reduced decoupling between systems, reduced segregation and efficiency, and a larger number of hub regions relative to young adults. Exploring the predictive utility of these age-related changes in network topology revealed high, albeit less efficient, performance for older adults whose brain graphs showed stronger dedifferentiation and reduced distinctiveness. Our results extend theoretical accounts on neurocognitive aging by revealing the compensational potential of the commonly reported pattern of network dedifferentiation when older adults can rely on their prior knowledge for successful task processing. However, we also demonstrate the limitations of such compensatory reorganization and show that a youth-like network architecture in terms of balanced integration and segregation is associated with more economical processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.