Evidence map›Paper›PMID 36190329›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2022

A (Controlled) Spill of IL2 for Localized Treatment of Mesothelioma.

Rohan Palanki, Kelsey L Swingle, Michael J Mitchell

Abstract readEditorialComment
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Rohan Palanki *Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0001-5168-5634
Kelsey L Swingle *Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0001-8475-9206
Michael J MitchellDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-3628-2244

Funding

In utero gene editing to cure a metabolic liver diseaseR01DK123049 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI PERANTEAU, WILLIAM H. · 2020 to 2024
$3.7M
Targeting stem-like cells and their niche in pancreatic cancerR37CA244911 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Tuomas Tammela · 2020 to 2026
$3.4M
A data-driven drug delivery (4D) platform for probing and treating the chemoresistant bone marrow microenvironmentDP2TR002776 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL, MICHAEL J · 2018 to 2018
$2.4M
Modular approach for the delivery of antibodies into the cytoplasm of cellsR01CA241661 · NCI · UNIVERSITY OF PENNSYLVANIA · PI TSOURKAS, ANDREW · 2019 to 2023
$1.8M
Ionizable Lipid Nanoparticles for Fetal Lung TargetingF30HL162465 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PALANKI, ROHAN · 2022 to 2025
$178k
NCATS NIH HHS DP2 TR002776NCI NIH HHS R01 CA241661NCI NIH HHS R37 CA244911NHLBI NIH HHS F30 HL162465NIDDK NIH HHS R01 DK123049
6 · The paper itself

Abstract

A microencapsulated, cell-based IL2 cytokine factory was recently developed, and the safety and efficacy of this platform in a mouse model of mesothelioma were demonstrated. This platform has the potential to overcome current challenges in the delivery of therapeutic cytokines for cancer immunotherapy. See related article by Nash et al., p. 5121.

Indexed as

MesotheliomaMesothelioma, MalignantAnimalsCytokinesImmunity, InnateInterleukin-2MiceCytokinesInterleukin-2

Identifiers

PMID36190329
PMCPMC10281013

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.