Evidence map›Paper›PMID 36190189›Full record

ArticleeLife2022

The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function.

Shasha Li, Michael D Bern, Benpeng Miao, Changxu Fan, Xiaoyun Xing, Takeshi Inoue, Sytse J Piersma, Ting Wang, Marco Colonna, Tomohiro Kurosaki and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. CD127International journal of molecular sciences · 2026
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  12. Article
  13. Transcriptional control of ILC identity.Frontiers in immunology · 2023
    Review
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Shasha LiDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, United States.ORCID 0000-0001-5924-6396
Michael D BernDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, United States.
Benpeng MiaoDepartment of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, United States.
Changxu FanDepartment of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, United States.
Xiaoyun XingDepartment of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, United States.
Takeshi InoueLaboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Sytse J PiersmaDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, United States.ORCID 0000-0002-5379-3556
Ting WangDepartment of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, United States.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, United States.ORCID 0000-0001-5222-4987
Tomohiro KurosakiLaboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan.ORCID 0000-0002-6352-304X
Wayne M YokoyamaDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, United States.ORCID 0000-0002-0566-7264
The University of Osaka · JP

Funding

The WashU-UCSC-EBI Human Genome Reference Center."U41HG010972 · NHGRI · WASHINGTON UNIVERSITY · PI Ira M Hall, Heng Li · 2019 to 2026
$24.9M
Natural Killer Cell Tolerance to SelfR01AI129545 · NIAID · WASHINGTON UNIVERSITY · PI Wayne M. Yokoyama · 2017 to 2026
$5.5M
DECODING THE IMPACT OF TRANSPOSABLE ELEMENTS ON GENE REGULATIONR01HG007175 · NHGRI · WASHINGTON UNIVERSITY · PI WANG, TING · 2014 to 2021
$2.7M
Connecting transposable elements and regulatory innovation using ENCODE dataU01HG009391 · NHGRI · WASHINGTON UNIVERSITY · PI COHEN, BARAK A, FESCHOTTE, CEDRIC · 2017 to 2021
$2.4M
NHGRI NIH HHS R01 HG007175NHGRI NIH HHS U01 HG009391NHGRI NIH HHS U41 HG010972NIAID NIH HHS R01 AI129545
6 · The paper itself

Abstract

BTB domain And CNC Homolog 2 (Bach2) is a transcription repressor that actively participates in T and B lymphocyte development, but it is unknown if Bach2 is also involved in the development of innate immune cells, such as natural killer (NK) cells. Here, we followed the expression of Bach2 during murine NK cell development, finding that it peaked in immature CD27

Indexed as

Basic-Leucine Zipper Transcription FactorsBTB-POZ DomainAnimalsCell DifferentiationChromatinCytokinesGranzymesKiller Cells, NaturalMiceTranscription FactorsBach2 protein, mouseBasic-Leucine Zipper Transcription FactorsChromatinCytokinesGranzymesTranscription FactorsBach2developmentimmunologyinflammationmouseNK cells

Identifiers

PMID36190189
PMCPMC9560152
OpenAlexW4300689768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.