Evidence map›Paper›PMID 36190119›Full record

ArticleeLife2022

Real time, in vivo measurement of neuronal and peripheral clocks in

Peter S Johnstone, Maite Ogueta, Olga Akay, Inan Top, Sheyum Syed, Ralf Stanewsky, Deniz Top

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Circadian Rhythms Time Seizure Severity inJournal of biological rhythms · 2026
    Article
  3. Article
  4. Article
  5. Intrinsic period stability of the cyanobacterial circadian oscillator across in vitro and in vivo conditions.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. Article
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  10. Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Peter S JohnstoneDepartment of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada.ORCID 0000-0002-9421-811X
Maite OguetaInstitute of Neuro- and Behavioral Biology, Westfälische Wilhelms University, Münster, Germany.
Olga AkayDepartment of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada.
Inan TopYou.i Labs Inc, Ottawa, Canada.
Sheyum SyedDepartment of Physics, University of Miami, Miami, United States.
Ralf StanewskyInstitute of Neuro- and Behavioral Biology, Westfälische Wilhelms University, Münster, Germany.ORCID 0000-0001-8238-6864
Deniz TopDepartment of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada.ORCID 0000-0002-1042-8460
Dalhousie University · CAUniversity of Miami · US

Funding

CIHR FRN-178220
6 · The paper itself

Abstract

Circadian clocks are highly conserved transcriptional regulators that control ~24 hr oscillations in gene expression, physiological function, and behavior. Circadian clocks exist in almost every tissue and are thought to control tissue-specific gene expression and function, synchronized by the brain clock. Many disease states are associated with loss of circadian regulation. How and when circadian clocks fail during pathogenesis remains largely unknown because it is currently difficult to monitor tissue-specific clock function in intact organisms. Here, we developed a method to directly measure the transcriptional oscillation of distinct neuronal and peripheral clocks in live, intact

Indexed as

Circadian ClocksDrosophila ProteinsAnimalsBiological ClocksCircadian RhythmDrosophilaDrosophila melanogasterDrosophila Proteinscell biologycircadian rhythmdistinct circadian clocksD. melanogastergeneticsgenomicsluminescencemethodneuronal clocksperipheral clocks

Identifiers

PMID36190119
PMCPMC9662830
OpenAlexW4300690737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.