Evidence map›Paper›PMID 36189921›Full record

ArticleeLife2022

RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification.

Erica J Hutchins, Shashank Gandhi, Jose Chacon, Michael Piacentino, Marianne E Bronner

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Elavl1 is dispensable for appendicular skeletal development.bioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Erica J HutchinsDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.ORCID 0000-0002-4316-0333
Shashank GandhiThe Miller Institute for Basic Research in Science, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-4081-4338
Jose ChaconDepartment of Biology, School of Math and Science, California State University Northridge, Northridge, United States.ORCID 0000-0001-7965-3976
Michael PiacentinoDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.ORCID 0000-0003-1773-031X
Marianne E BronnerDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.ORCID 0000-0003-4274-1862
California Institute of Technology · USCalifornia State University, Northridge · USMiller College · US

Funding

BUILD PODER IITL4GM118977 · NIGMS · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · PI CHAVIRA, GABRIELA, KHACHIKIAN, CRIST SIMON · 2015 to 2023
$18.1M
Cell lineage and transcriptional analysis of the vertebrate neural plate borderR01DE027538 · NIDCR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Marianne Bronner · 2018 to 2026
$4.4M
Clonal analysis of the cranial neural crestR01DE027568 · NIDCR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BRONNER, MARIANNE · 2018 to 2022
$2.2M
Characterization of the roles and regulation of Draxin in cranial neural crestR00DE028592 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUTCHINS, ERICA · 2022 to 2024
$1.1M
Characterization of the roles and regulation of Draxin in cranial neural crestK99DE028592 · NIDCR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI HUTCHINS, ERICA · 2019 to 2021
$414k
Characterizing the neural crest response to BMP signaling through gastrulation and neurulationK99DE029240 · NIDCR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI PIACENTINO, MICHAEL LOUIS · 2019 to 2021
$397k
NIDCR NIH HHS K99 DE028592NIDCR NIH HHS K99 DE029240NIDCR NIH HHS R00 DE028592NIDCR NIH HHS R01 DE027538NIDCR NIH HHS R01 DE027568NIGMS NIH HHS TL4 GM118977
6 · The paper itself

Abstract

While neural crest development is known to be transcriptionally controlled via sequential activation of gene regulatory networks (GRNs), recent evidence increasingly implicates a role for post-transcriptional regulation in modulating the output of these regulatory circuits. Using available single-cell RNA-sequencing datasets from avian embryos to identify potential post-transcriptional regulators, we found that

Indexed as

Gene Expression Regulation, DevelopmentalNeural CrestRNARNA-Binding ProteinsRNA, MessengerRNARNA-Binding ProteinsRNA, Messengerchickendevelopmental biologyDraxinElavl1HuRneural crestpost-transcriptional regulationspecification

Identifiers

PMID36189921
PMCPMC9529247
OpenAlexW4297409721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.