ArticleAdvanced materials (Deerfield Beach, Fla.)2022
Multifunctional 4D-Printed Sperm-Hybrid Microcarriers for Assisted Reproduction.
Article in Advanced materials (Deerfield Beach, Fla.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 60 citations in OpenAlex.
- Translational Application of Biomedical Microrobots in Female Reproductive System.ACS nano medicine · 2026Review
- Hybrid-Driven Bacillus Calmette-Guérin Carrier for Targeted Immuno-Chemo Combo Therapy in Bladder Cancer.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Autonomous Microrobots for Spatiotemporally Active Therapeutic Delivery and Controlled Release.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- PMSE Centennial: Celebration of Success and New Frontiers in Polymer Materials Science and Engineering.ACS macro letters · 2025Article
- Technology Roadmap of Micro/Nanorobots.ACS nano · 2025Review
- Micro- and Nano-Bots for Infection Control.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Review
- Multiorifice acoustic microrobot for boundary-free multimodal 3D swimming.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sperm cell empowerment: X-ray-guided magnetic fields for enhanced actuation and localization of cytocompatible biohybrid microrobots.npj Robotics · 2025Article
- Model-based reinforcement learning for ultrasound-driven autonomous microrobots.Nature machine intelligence · 2025Article
- Ex vivo validation of magnetically actuated intravascular untethered robots in a clinical setting.Communications engineering · 2024Article
- The utilization of nanotechnology in the female reproductive system and related disorders.Heliyon · 2024Review
- Spermbots and Their Applications in Assisted Reproduction: Current Progress and Future Perspectives.International journal of nanomedicine · 2024Review
- Application of micro/nanorobot in medicine.Frontiers in bioengineering and biotechnology · 2024Review
- Four-Dimensional-Printed Microrobots and Their Applications: A Review.Micromachines · 2023Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Remotely controllable microrobots are appealing for various biomedical in vivo applications. In particular, in recent years, our group has focused on developing sperm-microcarriers to assist sperm cells with motion deficiencies or low sperm count (two of the most prominent male infertility problems) to reach the oocyte toward in-vivo-assisted fertilization. Different sperm carriers, considering their motion in realistic media and confined environments, have been optimized. However, the already-reported sperm carriers have been mainly designed to transport single sperm cell, with limited functionality. Thus, to take a step forward, here, the development of a 4D-printed multifunctional microcarrier containing soft and smart materials is reported. These microcarriers can not only transport and deliver multiple motile sperm cells, but also release heparin and mediate local enzymatic reactions by hyaluronidase-loaded polymersomes (HYAL-Psomes). These multifunctional facets enable in situ sperm capacitation/hyperactivation, and the local degradation of the cumulus complex that surrounds the oocyte, both to facilitate the sperm-oocyte interaction for the ultimate goal of in vivo assisted fertilization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.