Evidence map›Paper›PMID 36189742›Full record

ArticleActa crystallographica. Section D, Structural biology2022

Dependence of crystallographic atomic displacement parameters on temperature (25-150 K) for complexes of horse liver alcohol dehydrogenase.

Bryce V Plapp, Lokesh Gakhar, Ramaswamy Subramanian

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta crystallographica. Section D, Structural biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 68% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Bryce V PlappDepartment of Biochemistry and Molecular Biology, The University of Iowa, Iowa City, IA 52252, USA.ORCID 0000-0001-6790-5363
Lokesh GakharProtein and Crystallography Facility, Carver College of Medicine, The University of Iowa, Iowa City, IA 52252, USA.ORCID 0000-0002-3319-1902
Ramaswamy SubramanianDepartment of Biochemistry and Molecular Biology, The University of Iowa, Iowa City, IA 52252, USA.ORCID 0000-0002-6709-190X
University of Iowa · US

Funding

SPECIFICITY OF ALCOHOL DEHYDROGENASESR01AA000279 · NIAAA · UNIVERSITY OF IOWA · PI PLAPP, BRYCE V · 1985 to 2004
$1.4M
Dynamic and Catalysis by Alcohol DehydrogenasesR01GM078446 · NIGMS · UNIVERSITY OF IOWA · PI PLAPP, BRYCE V · 2006 to 2009
$1.1M
NIAAA NIH HHS R01 AA000279NIGMS NIH HHS GM078446NIGMS NIH HHS R01 GM078446
6 · The paper itself

Abstract

Enzymes catalyze reactions by binding and orienting substrates with dynamic interactions. Horse liver alcohol dehydrogenase catalyzes hydrogen transfer with quantum-mechanical tunneling that involves fast motions in the active site. The structures and B factors of ternary complexes of the enzyme with NAD

Indexed as

Alcohol DehydrogenaseNADAmino AcidsAnimalsBenzyl AlcoholsBinding SitesCarbonCrystallography, X-RayFluorobenzenesFluorocarbonsHorsesHydrogenKineticsLiverProtein ConformationTemperature2,3,4,5,6-pentafluorobenzyl alcoholAlcohol DehydrogenaseAmino AcidsBenzyl AlcoholsCarbonFluorobenzenesFluorocarbonsHydrogenNADTrifluoroethanolalcohol dehydrogenasesanisotropic displacement parametersB factorsenzyme dynamicshelium cryostathydrogen transferTLS analysisX-ray crystallography

Identifiers

PMID36189742
PMCPMC9527765
OpenAlexW4297384369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.