Evidence map›Paper›PMID 36189308›Full record

ArticleFrontiers in immunology2022

Tumor necrosis factor receptor regulation of peripheral node addressin biosynthetic components in tumor endothelial cells.

Anthony B Rodriguez, Geoffrey Parriott, Victor H Engelhard

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anthony B RodriguezCarter Immunology Center and Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, United States.
Geoffrey ParriottCarter Immunology Center and Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, United States.
Victor H EngelhardCarter Immunology Center and Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, United States.
University of Virginia · US

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Jay William FOX · 1987 to 2026
$72.1M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
Quality and location of presented Ag as determinants of tumor-specific immunityR01CA078400 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ENGELHARD, VICTOR H · 1998 to 2012
$4.4M
Summer Research Experience in Cancer(SuRE-C)R25CA206972 · NCI · UNIVERSITY OF VIRGINIA · PI ADRIAN J HALME, Hui Zong · 2017 to 2026
$2.0M
Lymph node-like vasculature and naive T cell infiltration into tumorsR21CA181794 · NCI · UNIVERSITY OF VIRGINIA · PI ENGELHARD, VICTOR H · 2015 to 2016
$378k
NCI NIH HHS P30 CA044579NCI NIH HHS R01 CA078400NCI NIH HHS R21 CA181794NCI NIH HHS R25 CA206972NIAID NIH HHS T32 AI007496
6 · The paper itself

Abstract

Tumor-associated tertiary lymphoid structures are ectopic lymphoid aggregates that have considerable morphological, cellular, and molecular similarity to secondary lymphoid organs, particularly lymph nodes. Tumor vessels expressing peripheral node addressin (PNAd) are hallmark features of these structures. Previous work from our laboratory demonstrated that PNAd is displayed on intratumoral vasculature of murine tumors, and its expression is controlled by the engagement of lymphotoxin-α

Indexed as

Endothelial CellsNeoplasmsAnimalsLigandsLymphotoxin-alphaLymphotoxin-betaMiceReceptors, Tumor Necrosis FactorSulfotransferasesLigandsLymphotoxin-alphaLymphotoxin-betaReceptors, Tumor Necrosis FactorSulfotransferasesB16blood endothelial cellscarbohydrate sulfotransferasecheckpoint immunotherapyhigh endothelial venulesPNAdtertiary lymphoid structure

Identifiers

PMID36189308
PMCPMC9520236
OpenAlexW4295942662

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.