ArticleFrontiers in immunology2022
Long-term prognostic value of inflammatory biomarkers for patients with acute heart failure: Construction of an inflammatory prognostic scoring system.
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Neutrophil to lymphocyte ratio (NLR) prognostic effects on heart failure; a systematic review and meta-analysis.BMC cardiovascular disorders · 2023Pooled it
- The role of biomarkers across the care continuum in acute heart failure.Biomarker research · 2026Review
- Longitudinal Changes in Hematological Status and Functional Capacity During Hospitalization Are Associated With Clinical Outcomes in Older Patients With Acute Decompensated Heart Failure.Circulation reports · 2026Article
- Prognostic value of C-reactive protein-triglyceride-glucose index in hospitalised patients with acute decompensated heart failure.BMC cardiovascular disorders · 2026Article
- Predictive accuracy of serum IL-6, IL-17 and sST2 levels for diuretic resistance in patients with chronic heart failure.BMC cardiovascular disorders · 2026Article
- Low Serum Lysophospholipids Predict Increased In-Hospital Mortality in Patients With Acute Heart Failure.Journal of the American Heart Association · 2026Observational
- The C-reactive protein-to-body mass index ratio predicts prognosis in patients with different types of heart failure.Open medicine (Warsaw, Poland) · 2026Article
- Evidence for chronic inflammation in cats with cardiomyopathies.Journal of feline medicine and surgery · 2025Article
- Proteins associated with rehospitalization, mortality and diuretic resistance in acutely decompensated heart failure.ESC heart failure · 2025Article
- Risk factors for prolonged hospitalization in acute decompensated heart failure from the HEROES study.Scientific reports · 2025Article
- Prognostic Value of Modified Glasgow Prognostic Score in Acute Decompensated Heart Failure with Reduced Ejection Fraction.Journal of clinical practice and research · 2025Article
- Vitamin D as a Key Mediator Between C-reactive Protein to Albumin Ratio and Congestive Heart Failure in an Elderly Population: An Innovative Exploration Using the NHANES Database.Reviews in cardiovascular medicine · 2025Article
- Neutrophil-to-Lymphocyte Ratio as a Predictor of Mortality and Clinical Outcomes in Heart Failure Patients.Cureus · 2025Review
- The nonlinear correlation of neutrophil-lymphocyte ratio on 1-year mortality risk in patients with severe acute heart failure.BMC cardiovascular disorders · 2025Article
- Association between blood eosinophil levels and prognosis in critically ill patients with different heart failure phenotypes.Scientific reports · 2025Article
- Neutrophil-lymphocyte ratio (NLR) as an independent factor of 1-year mortality in patients with chronic heart failure with reduced ejection fraction.Cardiology journal · 2025Article
- The impact of inflammatory burden index on the prognosis in acute decompensated heart failure: evidence from a cohort study in Jiangxi, China.Frontiers in cardiovascular medicine · 2025Article
- Association between red cell distribution width-albumin ratio and all-cause mortality in intensive care unit patients with heart failure.Frontiers in cardiovascular medicine · 2025Article
- Assessment of platelet-to-white blood cell ratio on short-term mortality events in patients hospitalized with acute decompensated heart failure: evidence from a cohort study from Jiangxi, China.Frontiers in cardiovascular medicine · 2025Article
- Aggregate index of systemic inflammation as a novel prognostic biomarker in Chinese patients with acute decompensated heart failure: a population-based real-world study.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Systemic inflammation is associated with a poor prognosis in acute heart failure (AHF). This study was to assess the long-term prognostic value of combining the accessible inflammatory markers in relation to all-cause mortality in patients with AHF. Methods: Consecutive patients with AHF who were hospitalized between March 2012 and April 2016 at the Department of Cardiology of the First Affiliated Hospital of Nanjing Medical University were enrolled in this prospective study. The LASSO regression model was used to select the most valuable inflammatory biomarkers to develop an inflammatory prognostic scoring (IPS) system. Kaplan-Meier method, multivariate COX regression and time-dependent ROC analysis were used to assess the relationship between inflammatory markers and AHF prognosis. A randomized survival forest model was used to estimate the relative importance of each inflammatory marker in the prognostic risks of AHF. Results: A total of 538 patients with AHF were included in the analysis (mean age, 61.1 ± 16.0 years; 357 [66.4%] men). During a median follow-up of 34 months, there were 227 all-cause deaths (42.2%). C-reactive protein (CRP), red blood cell distribution width (RDW) and neutrophil-to-lymphocyte ratio (NLR) were incorporated into the IPS system (IPS = 0.301×CRP + 0.263×RDW + 0.091×NLR). A higher IPS meant a significantly worse long-term prognosis in Kaplan-Meier analysis, with 0.301 points as the optimal cut-off value ( Conclusions: Inflammatory biomarkers were associated with the risk of all-cause mortality in patients with AHF, while IPS significantly improved the predictive power of the model and could be used as a practical tool for individualized risk stratification of patients with AHF.
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